Featured

• Preferences for Obesity Medications Among People with Overweight or Obesity in the United States: A Discrete-Choice Experiment (OPTIC).
• Podcast: Food Noise Is Real, and Now We Can Measure It.
• RCT: Effects of Full-Fat and Low-Fat Fermented Dairy Foods on Markers of Cardiometabolic Health in Adults with Overweight or Obesity and Elevated Fasting Triglycerides.
• Meta-Analysis of RCTs: Impact of Milk Fat Globule Membrane and Its Associated Polar Lipids on Markers of Cardiometabolic Disease and Cognitive Function.

Headline vs Study

• Headline: Eating More Ultra-Processed Foods Linked to Worse Health, Study Finds.
• Press Release: Higher Ultra-Processed Food Intake Linked to Multiple Health Risks.
• Meta-Analysis of Observational Studies: Ultra-processed food and risk of multiple chronic diseases: "all studies relied on self-reported dietary assessments, which may not fully capture processing characteristics, ingredient composition, or UPF subtypes, leading to exposure misclassification and measurement error..."

Contrary or Null Findings

• "Contrary to our expectations, Necturus exhibited both absolutely and relatively larger jaw muscles than Salamandra and produced higher bite forces, even when scaled to the same size."
• "Contrary to hypothesis, NH and CB produced different metabolic responses despite reducing peripheral oxygen saturation."
• "Contrary to the prevailing view that brain L-serine is exclusively derived from de novo synthesis, we demonstrate that dietary L-serine is required to maintain brain L-serine levels and prevents the formation of neurotoxic 1-deoxysphingolipids."
• "Contrary to the conventional view that mtDNA damage is solely detrimental, we find that NTHL1 loss confers a beneficial, mitochondria-initiated phenotype in human cells."
• "Intriguingly, contrary to earlier literature, we detected elevated α-SMA expression upon BBR [berberine] treatment despite the suppression of cell migration, proliferation and collagen production."
• "Contrary to our predictions, circulating PYY concentrations did not increase following feeding, did not significantly differ between food-restricted and ad libitum birds, and were unrelated to either feeding latency or food consumption. Collectively, these findings fail to support the hypothesis that PYY functions as a conserved short-term satiety signal in zebra finches."
• "Contrary to expectations, urbanicity did not moderate the association between income and outdoor play."
• No Effect of Acknowledging Resistance or Using Autonomy-Supportive Language in Vlogs on Sustainable [Non-Meat] Consumption Intentions of Emerging Adults.

Basic

• Adipose Tissue Plays a Crucial Role in Obesity-Induced Postoperative Neurocognitive Disorders.
• Glucocorticoid Receptor Signaling Protects Human Mature Adipocytes from Metabolic Stress and Is Impaired in Obesity.
• Early Life High-Fat Diet Exposure Modulates Adult Metabolic Phenotypes in Drosophila.
• High-Swelling Edible Cellulose-Based Hydrogel for Gastric Filling and Satiety Induction.
• Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 Signaling Pathway in HGI C. Elegans.
• Obesity Increases Atherosclerosis Susceptibility Via an Intertissue MiR-30e-SLC7A11 Axis.
• Hyodeoxycholic Acid Suppresses Hepatic Steatosis in a PPARα-Dependent Manner Via Distinct GLP-1- and INKT Cell-Mediated Pathways.

Scientific Rigor & Scholarly Dialogue

• Preprint: Quantifying Evidential Rigor in Meta-Analytic Corpora: A Simulation-Characterized, Bias-Robust Bayesian Workflow with a Nutrition Case Study.
• Dietary Intake as an Undermeasured Potential Mediator: The Ethical Case for Complete and Transparent Dietary Reporting in GLP-1 Receptor Agonist Trials.
• Expert Reaction to UPF Consumption Linked to Higher Risk of Multiple Chronic Diseases.

Clinical

• The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain.
• RCT: Effects of a Self-Selected Vegetarian Vs. Omnivorous Diet on Protein Intake and Muscle Mass in Older Adults During Resistance Exercise.
• RCT: Declines in Plasma Erythritol and Improvements in Cardiovascular Risk and Atherogenic Lipid Profiles.
• Review: Obesity and Pelvic Organ Prolapse.

Children and Adolescents

• Motor Competence and Components of Metabolic Syndrome in Children and Adolescents with Overweight and Obesity.
• The Temporal Relationship Among Socioeconomic Vulnerability, Dietary Intake, and Childhood Obesity Across Six European Countries.
• Meta-Analysis: Association of Adverse Childhood Experiences and Overweight or Obesity in Adolescents.
• Meta-Analysis: Association between Overweight/Obesity with Depression, Anxiety, Low Self-Esteem, and Body Dissatisfaction in Children and Adolescents.
• Review: Adolescent Obesity: A Stepwise Clinical Approach.

Surgery

• Sentinel Lymph Node Mapping Versus Systematic Lymphadenectomy in Women with Obesity Undergoing Minimally Invasive Surgery for Endometrial Cancer.
• Comparative Analysis of Different Modifications of the Caprini Risk Score in Bariatric Surgery.
• Preprint: Efficacy and Safety of Employing an Intragastric Balloon to Manage Super Obesity, Either as a Standalone Treatment or in Combination with GLP-1 Receptor Agonists.
• RCT: Diabetes Remission 10 Years After Bariatric Surgery: Extension Study.
• Beyond Age and Comorbidities: Frailty and Cognitive Impairment are Associated with Early Medical Complications After Surgery for Lumbar Spinal Stenosis in Patients Aged 75 Years and Older.

Drugs

• Commentary: Tirzepatide for OSA and Obesity: Do We Know the Effect on Cardiometabolic Outcome?
• Interpretation of World Health Organization Guideline on Glucagon-Like Peptide-1 Therapies for Obesity in Adults.
• Targeting the Cardiohepatic-Metabolic Axis: GLP-1-Based and Incretin Multi-Agonist Therapies in MASH.

Food & Diet

• Intermittent Fasting Modulates Immune Signatures but Not TNF-Dependent Pathology in Mice with Constitutive STING Activation.
• Balancing Metabolism-Control of Weight Gain, Blood Glucose Levels and Intestinal Leakiness by Alpha-Lactalbumin-Oleic Acid Complexes.
• RCT: A Higher-Complex Carbohydrate vs Conventional Low-Carbohydrate Diet in Gestational Diabetes Mellitus Results in Lower Postprandial Free Fatty Acids.
• The Impact of Obesity on Appetite Regulation During Nutritional Ketosis.

Caloric and Dietary Restriction

• Diet-Responsive Proteogenomic Effects Following Short-Term Restriction of Animal Products in Humans.
• Direct Comparison of Serine Restriction on the Viability of Normal and Cancer Cells Demonstrates That Methionine Restriction Is More Cancer Specific.
• Impact of Caloric Restriction on Biological Aging: Insights from a Composite Biomarker Index in Older Adults.

Exercise & Physical Activity

• Meta-analysis: Physical Activity and Oxidative Stress Biomarkers in Humans.
• RCT: The Impact of a Lifestyle Intervention on Postpartum Physical Activity Among Predominantly Puerto Rican Women with Overweight and Obesity: Proyecto Mamá.

Economics & Sociology

• Association between Parental Socioeconomic Characteristics and Overweight and Obesity Among Adolescents.
• Associations of Work-Related Extended Availability with Overweight and Obesity Among Chinese Workers.
• Cardiometabolic Health in P'urépecha Migrant-Sending Communities in Michoacan, Mexico.
• Systematic Review: Co-Ethnic Exposure and Cardiometabolic Outcomes in Racial and Ethnic Minoritized Populations.
• County-Level Food-Related Implicit Associations, Socioeconomic Factors, Food Environment, and Health Outcomes.
• Dissertation: Insulin Resistance from the Inside Out: The Effect of Physiological and Neighborhood Factors on Insulin Resistance in Individuals with Overweight and Obesity.
• Socioeconomic Determinants Associated with Overweight and Obesity in Adults in Southern Tehran.

Epidemiology

• Population Burden of Diabetes, Hypertension, and Cardiovascular Disease Attributable to Obesity: A Community-Based Study in Türkiye.
• Obesity and Poor Sleep Quality - Prevalences and Risk Factors.
• Obesity and Outcomes After Esophagectomy.
• Associations of Body Fat Percentage-Based Obesity with Depression and Comorbidity-Related Gut Microbiota Features in College Students.
• Adiposity and Infection-Related Mortality: Mendelian Randomization Study of 126 000 Mexican Adults.
• Differential Expression of Human and Bacterial Proteins Reveals Microbiome-Host Crosstalk in Metabolic Disorders.
• A Landscape of Metabolic Burden and Its Cardiovascular Impact Across the Adult Lifespan.

Psychology & Neuroscience

• Genome-Wide Association Meta-Analysis of Eating Behavior Traits Revealed One Susceptibility Locus for Emotional Eating.
• Meta-Analysis: BMI and Regional Brain N-Acetylaspartate.
• What are the Experiences, Perceptions and Expressed Needs of Adolescents Living with Obesity and Their Mothers in Indonesia?
• Diet and Physical Activity Profiles Among College Students: Associations with Alcohol Use and 'Better for You' Product Choices.
• Dynamic Remodeling of Dentate Gyrus Microglia Underlies Adult Depression-Like Outcomes Following Adolescent High-Fat Diet Exposure.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Preprint: Cardiometabolic Dysregulation and the Social Determinants of Health in a Food Insecure Population.
• Dissertation: Early-Life Socioeconomic Disadvantage, Domain-Specific Self-Regulation, and Pediatric Obesity Risk.

Ethics

• Ethical Dimensions of Bariatric Surgery: A Narrative Review of Principles, Challenges, and Practice Implications.

Stigma

• Weight Stigma, Body Trust, and Suicide Ideation Among Adolescents: A Longitudinal Study.
• A Two-Way Street? Examining Nurses' Personal Experiences of Weight Bias in Clinical Settings.

Policy Related

• The Retail Food Environment Following a Mandatory Healthy Checkout Policy: A Natural Experimental Evaluation.
• Infant Diet Quality and Federal Nutrition Assistance Program Participation Predict Later Diet Quality in U.S. Children 2-5 Years Old.

Intergenerational Effects

• Asparaginase Methylation and Childhood Obesity.
• In-Utero Exposure to Maternal Hyperinsulinemia Impacts Glucose Homeostasis in Male Offspring Transiently.

Ecology, Evolution, & Energetics

• Impact of Meal Caloric Content on the Thermic Effect of Food in Adolescents with Obesity.
• Phosphodiesterase 4 Inhibition Attenuates Diet-Induced Obesity and Activates BAT Thermogenic Pathways Through Central Mechanisms.

Methods

• Discordance between BMI-Defined Overweight/Obesity and Waist-To-Height Ratio-Defined Central Obesity Among Adults with Type 2 Diabetes in Malawi.
• Causal Adiposity and Clinical Validation of Regional Fat Distribution in PMOS: A Multi-Modal Analysis Integrating GBD 2021, Mendelian Randomization, and Machine Learning.
• Longitudinal Validation of an Original Bias-Reduced Fat-Free Mass Metabolic Coefficient in Inpatients with Obesity.

Commentary

• Podcast: Expert Misinformation Online/Experts Correcting Experts? ROUNDTABLE.
• An Experiment to Explain the Success of Wegovy Tablets.
• Are GLP-1s Changing the Equation for Food Marketing?
• Human Milk as a Model for Next-Generation Infant Formula: Opportunities and Challenges.
• The Unique Metabolic Signature of Obesity and Stress.
• Health Benefits of Sardines.
• A Single RNA Shot Cut Visceral Fat 14% Without Muscle Loss.
• Podcast: "What if some of what we still teach about breast anatomy, milk supply, pumping, and milk ejection is based on an outdated understanding of how the lactating breast actually works?"

General

• Podcast: Do Lemmings Really Jump Off Cliffs?
• RCT: Effects of Acute Low-And Moderate-Dose Alcohol on Chronic Disease-Related Biomarkers in Healthy Light and Heavy Drinkers.
• "Contrary to general expectation, these findings indicate that fixed phone boxes do not reliably reduce suicide mortality, with two sites even showing increased rates after installation."
• 'Momnesia' Is Real - Scientists Find a Biological Explanation for Temporary Forgetfulness During Pregnancy.
• Phylogenomics and Museomics Reveal Five Distinct Species of Tiger Cats in South America.

Video & Audio

• Elizabeth McDonald, MD, PhD, on GLP-1 Agonists and Breast Cancer Incidence.

Announcements

• USDA's Operation SNAP Back Hits the Five Boroughs.