Featured

• RCT: Effect of Diet Macronutrient Content on the Cardiometabolic Response to Weight Loss.
• Adipose TGFβ-Asprosin Memory Promotes Obesity Relapse & Offspring Obesity Susceptibility.
• Psychometric Properties of a Fathers' Outcome Expectancies of Lifestyle Behaviors Instrument for Father-Child Reciprocal Reinforcement.
• ALKBH5 Activates Creatine-Driven Thermogenesis by Stabilizing CKB MRNA in Response to Cold.

Headline vs Study

• Headline: Are Vegans Hotter Than Meat Eaters? Experts Say Yes - in Three, Key Ways.
• Headline: Plant-Based Diets Could Help You Achieve Peak Physical Attractiveness, Scientists Say.
• Study: Narrative review of "plant-forward" diets (not necessarily vegan) and select measures of attractiveness. "...the selection process carries a risk of confirmation bias toward studies supporting the primary hypotheses."

Contrary or Null Findings

• RCT: "A self-selected vegan diet reduces protein intake, skeletal muscle mass, and MPS [muscle protein synthesis] in older adults" in "A self-selected vegan diet reduces skeletal muscle mass in healthy older adults."
• "Medicare Advantage was not associated with lower hemoglobin A1c, systolic or diastolic blood pressure, low-density lipoprotein cholesterol, or lower risk of food, housing, and transportation needs."
• RCT: "Although lower Lp(a) levels were observed with pelacarsen, the findings did not demonstrate that this translated into reduced cardiovascular risk in the overall study population."
• "Serum vitamin A and E concentrations in neonatal intensive care infants did not consistently reflect intakes" in "Associations between intake of vitamins E and A and serum concentrations in preterm infants."
• European Trials Find Non-Nutritive Sweeteners Do Not Undermine Weight Loss.
• RCT: "Overall, probiotic supplementation of S. boulardii in PCOS women did not affect weight, BMI, or FBS..."
• RCT: "UPF restriction did not result in significantly higher post-intervention [Highly Processed Food Withdrawal Scale] scores compared with generic energy restriction in free-living individuals with obesity..."
• RCT: "Moderate protein restriction does not increase basal autophagy in circulating immune cells of healthy adults, suggesting protein reduction alone, without caloric deficit, may be insufficient to activate autophagy in human blood."

Basic

• Obesogenic Diet Impairs Social Memory Through Alterations of Hippocampal CA2 Excitability and Oxytocin Signaling.
• Interleukin-4-Loaded Lipid Nanoparticles Reprogram Adipose Tissue Immunity and Promote Adipocyte Browning for the Treatment of Obesity.
• N-Terminal Thrombospondin-1 Enhances Muscle Function and Tissue-Specific Metabolic Adaptation in Response to Exercise and Cold Exposure.
• Adipose Tissue Remodeling Beyond Weight Loss: New Insights Into Incretin-Based Therapies and Bariatric Surgery.
• Review: The Gut Microbiome-Cardiometabolic Axis: Insights Into Obesity, Type 2 Diabetes, and Hypertension.
• Adipocyte-Specific Deletion of Adrenomedullin Exacerbates High-Fat Diet-Induced Hypertension.
• Increased Energy Expenditure Through Intermittent Cold Exposure Does Not Enhance Tirzepatide Induced Weight-Loss in Obese Mice.

Scientific Rigor & Scholarly Dialogue

• Audit of Abdelbasset et al. (2019): Three Randomized Controlled Trials on Exercise and Depression.
• Corrigendum: Does Severe Obesity Define a Threshold over Which Robotic Sentinel Lymph Node Mapping Outperforms Laparoscopic Mapping in Endometrial Cancer?
• No, Those Raspberries Didn't Cut Your Risk of Death by 14%.
• Retraction: Protective Effects of Calorie Restriction and 17-β Estradiol on Cardiac Hypertrophy in Ovariectomized Obese Rats.

Clinical

• Why Do We Lose Bone During Weight Loss: Can It Be Prevented?
• Social Support and Perceived Dietary Barriers Mediate Weight Loss in the AMPLIFY Web-Based Diet Intervention.
• Generative AI: Digital Health in Obesity Care: Current Evidence, Challenges, and Future Directions.
• A Comprehensive Obesity Benefit: Guidance for Occupational and Environmental Medicine Professionals.

Children and Adolescents

• Physician-Related Predictors of Referral for Multidisciplinary Paediatric Obesity Management: A Population-Based Study.
• Meta-Analysis: Mindfulness-Based Interventions for Improvement of Lifestyle Behaviors and BMI in Children with Overweight or Obesity.
• One in Four Children Experience BMI Increase After Lower Extremity Surgery Without Return to Preoperative Levels.
• Comparing Two Diagnostic Frameworks for Obesity in Mexican Children Attending a Pediatric Obesity Clinic.

Surgery

• Review: Adipose Tissue Remodeling Beyond Weight Loss: New Insights Into Incretin-Based Therapies and Bariatric Surgery.
• Cohort Study: Associations between Obesity Phenotypes Defined by BMI and Waist Circumference with Postoperative Complications and Mortality.
• Observational Study: Comparative Evaluation of Sternomental and Hyomental Distance-Based Dynamic Airway Indices for Predicting Difficult Laryngoscopy in Surgical Patients with Obesity.
• Cohort Study: Abdominal Compartment Syndrome Following Major Abdominal Surgery.
• Retrospective Study: Association between BMI and Two-Year Clinical Outcomes Following Surgical Treatment of Insertional Achilles Tendinopathy.
• Where Does Surgery Fit in the Era of Effective Obesity Pharmacotherapy? Positioning Metabolic Bariatric Surgery Within Multimodal Obesity Care.

Drugs

• Scientific Statement: Obesity Science, Research Gaps, and Opportunities in the New Era of Obesity Medicines: an Endocrine Society Scientific Statement.
• RCT: Safety, Pharmacokinetics and Pharmacodynamics of the GLP-1/GIP/GCG Receptor Agonist UBT251 Injection.
• Meta-Analysis of RCTs: Tirzepatide and the Incidence of Atrial Fibrillation in Adults with Overweight or Obesity.
• Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity.
• Females are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.
• Nationwide Real-World Retrospective Study of Oral Semaglutide Use in Adults Living with Type 2 Diabetes in Finland.

Food & Diet

• Reductions in Sugar-Sweetened Beverage Intake and Weight are Maintained Following a Digital Health Intervention.
• Does Protein Source Influence Ageing Muscle? A Contemporary Physiological Perspective.
• RCT: Sweet Relief: Effectiveness of Dark Chocolate for Managing Menstrual Cycle-Related Symptoms in Female Athletes.
• Review: Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies.

Caloric and Dietary Restriction

• Beyond Weight Loss: Disentangling the Direct Effects of Semaglutide vs Equivalent Calorie Restriction on Reproductive Systems of Male and Female Rats.
• Caloric Restriction Modulates Genome-Wide Somatic Mutation in Mice.
• Influence of Different Degrees of Food Restriction on Immune Function and Gut Microbiota in Brandt's Voles.

Exercise & Physical Activity

• Comparative Effectiveness of Aerobic Exercise Versus Resistance Training on Cardiometabolic Health in Patients with Diabesity.
• Systematic Review: Exercise Modalities for Adults with Type 2 Diabetes Mellitus and Obesity: Comparative Effects on Visceral Fat, Metabolism, and Inflammatory Markers.
• RCT: Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults with Obesity.
• RCT: Acute Appetite and Gut-Hormone Responses to Two Combined Training Sessions in Men with Obesity.
• Secular Trends in Physical Fitness and Nutritional Status Among Tibetan Children and Adolescents from 2005 to 2019.

Economics & Sociology

• Heterogeneous Effects of Working Time Reduction on Overweight: Evidence from France.
• Association between Mukbang and Cookbang Watching and Obesity in Korean Adolescents.
• Lifestyle Intervention Powered by Sport Fandom in Men with Overweight or Obesity: A 1-Year Cost-Effectiveness Analysis of the Hockey FIT Trial.
• Cost-Effectiveness of Access to Obesity Care and Treatments for Adolescents.
• Medical Expenditures by BMI Among Privately Insured US Adults Aged 18 to 64 Years, 2022.
• Cost-Effectiveness of Semaglutide 2.4 mg for Obesity Disease Management in Japan: A Lifetime Economic Modeling Study Incorporating Retreatment Scenarios.
• Abstract: Does Living with Obesity During Tertiary Education Affect Employment Outcomes After Graduation? Longitudinal Evidence on 1,673 Young Adults in China.
• Association of BMI Categories with Healthcare Use and Health Expenditures in Switzerland.
• Clinical and Economic Burden of Obesity and Cardiovascular Disease Among Medicare Fee-For-Service Beneficiaries.

Epidemiology

• Redefining Obesity Risk for Heart Failure: Incorporating Morbidity Into the 2024 EASO [European Association for the Study of Obesity] Framework Definition of Obesity.
• Clinician Counseling and Weight Loss Attempts Among Survivors of Obesity-Associated Cancers.
• Characteristics of Patients with Acute Respiratory Failure in Obesity Hypoventilation Syndrome in the Intensive Care Unit.
• Meta-Analysis: Global Prevalence of Sarcopenic Obesity Defined by European Society for Clinical Nutrition and Metabolism/European Association for the Study of Obesity Criteria.
• Prepregnancy BMI, Pregnancy Physical Activity Trajectories, and Postpartum Blood Pressure.
• Review: Adverse Outcomes of Sarcopenic Obesity in Older Adults.
• Cohort Study: Follow-Up Longitudinal Observational Study on Risk Factors and Health in Adults.
• Diagnostic Variability in Sarcopenia and Sarcopenic Obesity Among Older Adults: A Clinical and Public Health Challenge.

Psychology & Neuroscience

• Psychological Characteristics of Patients from Obesity Treatment Program in Gdańsk.
• Cross-Sectional Study: Physical Activity Moderates Links between Weight Misperception and Adolescent Mental Wellbeing.
• "My Body Is Weary from Weight, My Mind from Criticism" Experiences of Women Living with Obesity in Turkiye.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Weighed Down by Paperwork: Identifying Barriers to Metabolic and Bariatric Surgery Evaluation in the United States.
• Cohort Study: Whole-Population Trends in Obesity Across Dimensions of Inequality in England, 2019-25.
• Cohort Study: Sociodemographic and Socioeconomic Differences in the Use of Anti-Obesity Medications.
• Systematic Review: Socioeconomic Inequalities in Exposure to Neighborhood Food Environments.
• Obesity and Food Insecurity Among College Students in the Alabama Blackbelt.

Stigma

• The Role of Shame and Self-Esteem in the Relationship between Internalized Health-Related Stigma and Mental Health Symptoms in Adults with Chronic Health Conditions.
• Weight Discrimination and Disordered Eating Behaviors Among Young Adults with High Weight Status.
• Associations between Specific Forms of Teasing and Body Image Dissatisfaction in Adolescents.

Policy Related

• Steering Biofortification of Zn, Fe and Se in Staple Cereals (Wheat, Maize and Rice) for Micronutrient Hunger Mitigation: From Trials to Industrialized Food Products.
• Report: Food as Medicine in Los Angeles County: Policy and Practice Insights 2025.
• Exploring the Practices of Healthcare Practitioners During the Implementation of a Healthy Eating Policy.

Intergenerational Effects

• Gestational Weight Loss Relative to Prepregnancy Weight in Women with Gestational Diabetes: Impact on Maternal and Neonatal Outcomes.
• Influence of Maternal Obesity, Gestational Weight Gain and Gestational Diabetes on Child Metabolic Profile: A Prospective Study from the Intrauterine Period Until Early Childhood.

Ecology, Evolution, & Energetics

• Early-Life Environment Drives Long-Term Decrease in Adult Body Mass in a Wild Bird Population.
• Evolutionary Mismatch between Stomach Capacity and Modern Diets: Implications for Obesity and Metabolic Disease.
• Integrated Transcriptomic Analysis of MRNA and miRNA in Brown Adipose Tissue of the Greater Horseshoe Bats During Hibernation.
• Fine-Scale Body Condition Dynamics in Elk Revealed by Implanted Bioimpedance Biologgers.

Methods

• Obesity Definition by Percentage of Body Fat Compared to BMI in a Kidney Transplant Transition Clinic.
• Preprint: Reclassification of Hypertension Risk Using an Adiposity-Based Obesity Definition in Two Prospective Cohorts.
• Validity and Utility of Self-Reported Weight Gain Since Age 20 in a 30-Year-Old Japanese Working Population.

Commentary

• Podcast: "We also consider the broader implications for the use of processing-based classifications in nutrition science and whether this adds meaningful explanatory value beyond traditional assessments of diet quality."
• Podcast: More Coffee or Better Focus? The Surprising Science of Caffeine & Breathing | Dr Sedat Arslan.
• Women Who Ate More Antioxidants Had Strikingly Lower Rates of Cervical Cancer.
• Podcast: Physionic rebuts claim that "Fiber's Health Benefits are Built on FLAWED Research."
• Podcast: Metabolic Effects of Diet Composition on Weight Loss Outcomes.
• Sanctimonious Food Policy Won't Help.
• Is Sugar Toxic? Can It Cause Cancer? Gary Taubes.

General

• Disruption of the Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans Dramatically Increases Male Longevity and Enhances Reproductive Health Late in Life.
• When Wine Walked Into Grocery Stores: Examining the (Un)intended Economic Consequences of Wine Sale Reform in Tennessee.
• Editorial: The World Bank is right to prioritize reproducibility: The development bank and others are starting to publish and verify the raw data and code accompanying their research-based reports and papers. Other agencies should do the same.
• Understanding NIH's Unified Funding Strategy: What the Research Community Needs to Know.
• Highly Potent Compound Blocks Ebola Virus Infection and Improves Survival in Animal Model.
• Effects of a Reintroduced Tiger Population on Large Carnivores in Panna Tiger Reserve, Central India.
• Preprint: Dietary Traits, Systemic Inflammatory Proxies, and Insomnia-Related Outcomes: Exploratory Mendelian Randomization and Population-Based Evidence.

Announcements

• "Balas has been conducting research on research for more than a decade, and the grant from NIH's National Institute of General Medical Sciences will allow his team to create a database consisting of prevalent research defects and develop prevention measures that researchers can use to ensure their studies are accurate and reproducible."
• 2026 Gill Symposium to Honor Leading Researchers Behind GLP-1 and Incretin Biology Breakthroughs.
• Webinar: Microplastics Analysis in Food: Current Challenges & Opportunities for Standardization. September 22, 2026.
• Arkansas Children's Hospital Nationally Ranked in 9 Specialties, 1st in Arkansas, and 2nd in Southeast Region, by US News and World Report.