09/04/26
Featured
- A Geroprotective Probiotic and Its Functional Metabolite Counteract Inflammaging to Extend Healthspan.
- Early-Life Supplementation of Bovine Milk Osteopontin Prevents Adult Obesity by Elevating Succinic Acid and Acting Through Its Receptor GPR91 [in Mice].
- Food Insecurity and Cardiovascular-Kidney-Metabolic Syndrome-Related Conditions Among US Adults, National Health and Nutrition Examination Survey, 2015-2020.
- For Weight Loss: Why Do GLP-1 Agonists Work, and How Can We Make Them Work Better?
- RCT: Understanding the Metabolic and Endocrine Effects of Macronutrient Boluses in the Context of a Low-Carbohydrate Diet.
Headline vs Study
- Headline: New Weight Loss Drug May Burn Fat Without Muscle Loss Seen in GLP-1 Drugs.
- Press Release: A Promising New Weight Loss and Diabetes Treatment Helps Burn Fat While Keeping Muscle.
- Study: A Multi-Functional Oral Small Molecule Targeting Energy and Lipid Metabolism to Treat Obesity and Related Metabolic Disorders... In Mice and Immortal Cell Lines.
Contrary or Null Findings
- RCT: "Food processing did not affect short-term satiety."
- "Pediatric counseling in routine clinical practice is not independently associated with physical activity in children." (PDF)
- RCT: "Acute and Short-Term GSE [Grape Seed Extract] Intake Did Not Significantly Affect Post-Exercise Hypotension …However, GSE Intake at the End of This Period Transiently Increased Resting BP 90 Min After Ingestion."
- "Dietary SFA absorption did not explain individual variation in serum LDL-cholesterol response to SFA replacement with UFA [unsaturated fatty acids]."
- RCT: "The intervention produced a small increase in self-reported goal priority, which was not maintained at follow-up, and had no significant effect on adherence across the MD components relative to control."
- RCT: "Although vitamin D supplementation effectively increased serum 25(OH)D concentrations, it did not reduce central adiposity among male shift workers."
- "In this exploratory cohort of adults with chronic HF, type 2 DM, and overweight or obesity, no statistically significant racial or ethnic differences were identified in the dietary and laboratory measures examined."
- RCT: "Binary logistic regression revealed a reduced likelihood of dietary supplement use in the experimental group compared to the control group post intervention, but this difference was not statistically significant."
Basic
- CFTR Regulates Lipid Metabolism by Relieving Adipose Inflammation in Obesity.
- Atorvastatin Exerts Context-Dependent Metabolic and Beneficial Effects on Behavior and Apoptotic Signaling in a Cafeteria Diet-Induced Metabolic Dysfunction Model.
- ASB3 Limits Adipocyte Thermogenesis and Energy Expenditure Through P62 Ubiquitination.
- Hepatic MED1 Disruption Ameliorates Obesity-Related Fatty Liver by Attenuating SREBP1-Driven Lipogenesis.
- Intestinal Fructose Catabolism Promotes Obesity and Insulin Resistance Via Ileal Lacteal Remodeling.
- Transcriptomic Profiling of Human Brown and White Adipose Tissue Depots.
- Natural Microbiota Confer Life-Long Protection Against Obesity Via an Early-Life, Immune-Mediated Effect on Brown Adipocytes.
Scientific Rigor & Scholarly Dialogue
- Expert Reaction to Keto Diet Has More Health Benefits over Other Popular Weight-Loss Diets.
- Podcast: Do We Really Eat Too Much Protein?
- Podcast: "In today's episode of Bite Back with Abbey Sharp, we're breaking down some of the biggest myths about soy and separating hormone fearmongering from the actual science."
- Letter: The Challenge of Dose-Specific Comparisons in Obesity Pharmacotherapy.
- Response: The Challenge of Dose-Specific Comparisons in Obesity Pharmacotherapy.
Clinical
- Podcast: Inositol or Vitamin B8 for Weight Loss on Nutrition Advice.
- Development of Program Requirements for Obesity Medicine Fellowship Training in the U.S.
- The Development and Pilot Testing of a Shared Decision-Making Encounter Aid for Weight Management Decisions.
- Scalable Behavioural Weight Management Programmes for the Prevention and Treatment of Type 2 Diabetes.
- RCT: Meal Replacement Provides Additional Benefits for Weight and Visceral Fat Reduction in Prediabetic Individuals.
- From Adiposity to Multisystem Morbidity: The Case for Weight Loss as Disease Modification.
- Adult Overweight and Obesity Management: Updates from the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines.
Children and Adolescents
- Residential Accessibility to Indoor and Outdoor Physical Activity Facilities and Overweight/Obesity Among Chinese Preschool Children in 551 Cities.
- Embedding the MapMe Intervention Into the English National Child Measurement Programme: A Within-Trial Cost Utility Analysis.
- Documenting Two Decades of Longitudinal Changes to a Community-Engaged Obesity Prevention Intervention for Native American Families to Facilitate Scale-Up.
Surgery
- Cost-Effectiveness of Endoscopic Sleeve Gastroplasty Using a Disease Progression Model.
- Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain After Bariatric Surgery.
Drugs
- Understanding Self-Reported Treatment Behaviors Among People Using Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss.
- Discontinuation of Semaglutide Therapy for Obesity Management.
- Out-of-Pocket Costs and Adherence to Semaglutide for Obesity Among Commercially Insured Adults.
- Real-World Effectiveness and Safety of GLP-1 Receptor Agonists Among Patients with Weight Recurrence After Bariatric Surgery.
- Longitudinal Changes in Body Composition, Adaptive Thermogenesis and Muscle Strength in Patients with Obesity Treated with Semaglutide.
- Effects of Semaglutide Versus Bariatric Surgery on Noninvasive Markers of Hepatic Steatosis and Fibrosis in Obesity with MASLD.
Food & Diet
- Review: A Critical Review of the Science on "Highly" Processed Food Intake and Body Weight.
- RCT: Effect of Diet Macronutrient Content on the Cardiometabolic Response to Weight Loss.
- RCT: Lactose and Sucrose Each Stimulate Hepatic De Novo Lipogenesis.
- Meta-Analysis: Effects of High-Quality Protein Supplementation on Lipid and Lipoprotein Profiles in Adults with Overweight or Obesity.
- Systematic Review: Effects of the Mediterranean Diet, Ketogenic Diet, and Intermittent Fasting on Iron Metabolism and Iron Deficiency Risk in Adults with Obesity.
Caloric and Dietary Restriction
- Effects of Caloric Restriction on Cognitive Function, Inflammation, and the Gut Microbiota in Aged Mice Fed a High-Fat Diet.
- RCT: Third-Trimester Energy-Restriction or Weight Loss and Maternal and Child Body Composition One Year Postnatally After a Pregnancy with Gestational Diabetes: Results from the DiGest Follow-Up Study.
- Adipose FGF21 Signaling Mediates the Anti-Senescence Effects of Protein Restriction.
- Time-Restricted Feeding Reverses Kidney Fibrosis Through Reduced CD8+ T Cell Infiltration in Obese Mice.
- Effects of Caloric Restriction and Different Diet Types on Weight Loss, Metabolic Profile and Behavior of Overweight and Obese Dogs.
- Systematic Review: Effect of Lifestyle Interventions on Pediatric Obesity.
Exercise & Physical Activity
- RCT: Exercise-Induced Compensation and C-Reactive Protein Change in Adults with Elevated C-Reactive Protein.
- Meta-Analysis: Optimal Exercise Dose for Resistance Training to Improve HbA1c Levels in Obese Patients with Overweight or Obesity and Type 2 Diabetes.
- Meta-Analysis: Study-Level Age Patterns in Cardiometabolic Response to High-Intensity Interval Training Among Adults with Overweight or Obesity.
- Meta-Analysis: Which Exercise Modality Improves Vascular Function Most in Adults with Overweight or Obesity?
Economics & Sociology
- Neighborhood Effects on Black Adolescents' Obesity Risk: The Mediating Role of Family Experiences.
- Trends in Cost of Care with Tirzepatide in Adults Aged over 55 Years with Obesity or Overweight Without Diabetes: A Matched Cohort Analysis.
- Preprint: Long-Term Cost and Health Impact of a Digital Obesity Intervention in Germany: Economic Modeling Study.
- Rising Food Prices and Widening Nutrition Gaps in Mexico: The Cost of Nutrient-Dense and Ultra-Processed Foods Before, During, and After COVID-19.
Epidemiology
- Obesity and Cardiovascular Diseases.
- The Microplastic-Gut Microbiota Axis: A Unifying Framework Linking Environmental Pollution to Undernutrition, Obesity, and Metabolic Dysfunction.
- Development and Internal Validation of a Risk Score for Incident Obesity Among Peruvian Formal Workers.
- Epidemiology of Osteoarthritis Overall and by Body Mass Index Category in the United States.
- Preprint: Calibrating Self-Reported BMI in National Surveillance: Impact on Obesity Misclassification and Socioeconomic Inequalities in Portugal.
- AI: The Forcing Factors That Predict Obesity: A Cross-Sectional Multilevel Machine Learning Model of US County-Level Prevalence.
- Beyond BMI: Genome-Wide Associations of Visceral Fat, Fat Mass, and Fat-Free Mass in Eastern Asian Populations.
Psychology & Neuroscience
- Sociocultural Considerations in Food Addiction and Emotional Eating.
- Appointment Adherence, Weight Reduction, and Retention at 9 Months in Australian Clinical Obesity Services: A Retrospective Cohort Study.
- Neural Dissociation between Liking and Wanting in Successful Versus Unsuccessful Restrained Eaters: Brain Responses to Wanting are Associated with Daily Dietary Control.
- Glucose-Lowering Therapies and Cognitive Decline: From Molecular Mechanisms to Clinical Evidence and Future Perspectives.
- Between Hope and Weight: Psychological Experiences of Women with Obesity Facing Preoperative Weight-Loss Requirements for Breast Reconstruction-A Qualitative Thematic Analysis.
Differential Population Circumstances, Exposures, Outcomes, and Effects
Stigma
- Maternal Parenting Strategies and Daughters' Perceived Weight Teasing as Predictors of Restrictive Eating Behaviors.
- Review: Self-Discrepancy Theory: Conceptualizing Internalized Weight Bias in Adolescents with Obesity.
Policy Related
- Review: Alignment of Food Policies and Cardiovascular Disease Burden: Insights from the Literature.
- Health, Social and Economic Impacts of the UK Treasury Soft Drinks Industry Levy: A Synopsis of a Systems-Thinking Informed Multi-Method Evaluation.
- Eyes on the Fries: An Eye-Tracking Study of Motivated Attention and Calorie Labeling on Fast-Food Menus.
- Loss of Access to Universal Free School Meals and Body Mass Index in Students.
Intergenerational Effects
- Maternal Obesity Prolongs the Adolescent Growth Spurt in Rat Offspring and Increases Weight Gain in a Sex-Specific Manner.
- Preprint: Early-Life Poverty, Social Disadvantage and Adiposity from Childhood to Young Adulthood.
- Metformin and Hypertensive Disorders of Pregnancy: A Phenotype-Based Focused Narrative Review.
- Major Dietary Protein Sources During Pregnancy and Obesity Risk in Mothers and Offspring: A Prospective Cohort Study.
Ecology, Evolution, & Energetics
Methods
- Creation and Validation of the 8-Item Brief Emotional Eating Scale (BEES-8, Version 1.0) in Youth and Adults.
- Validity and Predictors of Medical Claims Coding for the Identification of Patients with Obesity.
Commentary
- Podcast: Why Some Foods are So Hard to Stop Eating | Dr. Dana Small & Mike Haney.
- Podcast: "Go Ask Alice" - Dr. Lichtenstein explains the health effects of dietary fats.
- A 'Heart-Healthy' Diet Is Worth the Effort. Isn't It?
- Fad or Fact: Is Gelatin Really 'Nature's Ozempic'?
- Gray-Market Retatrutide: Less Weight Loss, More CV Effects.
- Unraveling the Mystery of GIP Agonism and Antagonism.
- The Scientific and Ethical Arguments for Ending Food Stamps.
- Behavior Change Support in the New Era of Obesity Care.
General
- Podcast: How Does Butter Get Its Texture, Flavor, and Color?
- Claim That Science Is Becoming Less Disruptive Challenged After Years-Long Publication Delay.
- Current Evidence, Controversies, and the Future of Biotics in the Prevention of Necrotizing Enterocolitis: A Narrative Review.
- Metabolic Control of Smooth Muscle Cell Phenotype Switching in Atherosclerosis.
- Managing Testosterone Deficiency in Primary Care: An International Expert Consensus.
- Dolly Parton Dies Aged 80 - Researchers Celebrate Her Contributions to Science.
- AI: TrialScout Links Published Results to Trial Registrations Using a Large Language Model.
- Selection Into Medicine.