Featured

• Report: Engineering Food Systems to Enable Precision Nutrition.
• Partial Depletion of Plasminogen Activator Inhibitor-1 Decreases Subcutaneous Fat Cell Hypertrophy and Liver Cholesterol in High-Fat-Fed Female Mice.
• High-Fat Diet Exposure, Internal State, and Reward Value Influence Decision Making During Motivational Conflict.

Headline vs Study

• Headline: The Diet That Lets You Eat More - and Beats Weight Watchers in the Long Term: Study.
• (Better) Headline: Popular Diet May Not Help for Weight, but Trial Points to Another Benefit.
• Press Release: UNC Study Finds Mediterranean-Style Eating Supports Weight Loss and Improves Diet Quality.
• Study: "...there was no statistically significant difference in percentage of body weight loss at the 24-month follow-up [the registered primary outcome] between participants receiving the Mediterranean-style or control intervention."

Contrary or Null Findings

• Mega-Analysis of RCTs: “When Calorie Labels Were Present (versus Absent) Energy Purchased Per Transaction for Main Meals Increased …There Was No Evidence of Differences in Energy Purchased Per Transaction from Discretionary Foods…or Drinks …there Was No Clear Evidence That Labels Reduced Energy Purchased in Any of the Categories.”
• RCT: "In this randomized clinical trial comparing a Mediterranean-style weight loss intervention to a control intervention, there was no material difference in percentage change in body weight at the 24-month follow-up visit between participants in these programs."
• Pre-print RCT: "...the lack of significant differences in the other fall risk metrics may be indicative of insufficient duration and/or intensity of the intervention."
• Full-Fat Dairy Shows Benefits Without Raising Body Fat or Cholesterol, Study Finds.
• RCT: "the primary outcome did not reach statistical significance" in "Strength training during pregnancy for the prevention of gestational diabetes...in women with overweight or obesity.”
• RCT: "There were no significant differences between groups in growth and morbidity outcomes" in "Donor human milk for maternal milk shortfall in preterm infants."
• RCT: "the structured protocol did not demonstrate superiority over the minimal active physiotherapy comparator for fatigue, quality of life, muscle strength, or functional capacity" in "Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients".
• RCT: "These findings suggest that TRE may be a safe approach for reducing HbA1c levels in T1D, although not more effective for weight loss compared with CR or a control group."

Basic

• Interleukin-19 Regulates Adipose Tissue Dysfunction in Obesity: Interplay between Inflammation and Vascularization.
• Broussoflavonol F Alleviates Obesity-Associated Metabolic Syndrome in Obese Mice by Modulating Gut Microbiota.
• Loss of Mitochondrial Co-Chaperone GRPEL2 Protects Mice from Age- and Diet-Induced Obesity.
• Multi-Organ Proteomic Atlas of Obesity Regression in Male Mice.
• Sphingosine Kinase 2 Regulates Adipocyte Browning and Whole-Body Metabolism.
• Intestinal CGAS-STING-IFN Signalling Promotes Obesity by Downregulating Microbiota-Derived IAA in Male Mice.
• Depot-Dependent Biology of Human Adipose Tissues and Metabolic Health.
• Mechanistic Drivers of Thermogenic Adipose Tissue Dysfunction in Aging and Obesity.

Scientific Rigor & Scholarly Dialogue

• The Challenges of Performing Controlled Trials of Diet Therapies in Gastroenterology.
• Blog Post: What Contributions Can Academic Statisticians Make to Sports Analytics? (A Discussion Related to the Launch of the New Open-Access Journal of Statistics and Data Science in Sports).
• Retraction: Meta-Analysis of the Association between the Dietary Inflammatory Index and Risk of Chronic Kidney Disease.

Clinical

• Challenging the Obesity Paradox: A Multicenter Study of BMI and Mortality in Venovenous Extracorporeal Membrane Oxygenation.
• LTE: Beyond Body Mass Index: Redefining Obesity Prevalence in an Italian Cohort of People Living with HIV According to the New Lancet Commission’s Excess Adiposity Criteria.
• Comparing the Diagnostic Characteristics of Neuropathy Questionnaires in Adults with Obesity.
• Review: Does the Carbohydrate-Insulin Model Explain Obesity? Evidence from Mechanistic and Clinical Studies.

Children and Adolescents

• Linking Pediatric Obesity to Youth-Onset Type 2 Diabetes.
• Can Weight Status in the First Year of Life Predict Well-Being in the First Years of School?
• A Pilot Study of Acceptance-Based Behavioral Weight Loss for Adolescents with Obesity.
• Systematic Review: Involvement of Fathers in Pediatric Obesity Treatment and Prevention Trials.
• Centiles for Energy Costs of Tissue Deposition in Infancy, Childhood and Adolescence: Calculations Based on Reanalysis of UK Body Composition Reference Data.

Surgery

• Cohort Study: Associations of Bariatric Surgery with Apolipoprotein A1, Apolipoprotein B, and Apolipoprotein B/Apolipoprotein A1 Ratio.
• The Role of Bariatric Surgery in Kidney Disease: Evidence, Controversies, and Future.
• Propensity Matched Analysis: Associations of Bariatric Surgery with Dementia in Patients with Diabetes and Obesity.
• Meta-Analysis: Metabolic and Bariatric Surgery in Adults with Obesity and Diabetes Mellitus.

Drugs

• A Multi-Functional Oral Small Molecule Targeting Energy and Lipid Metabolism to Treat Obesity and Related Metabolic Disorders.
• RCT: Efficacy and Safety of Mazdutide in Adults with Obesity or Overweight.
• Meta-Analysis: Cardiometabolic Effects of Dual GLP-1 and Glucagon Receptor Agonists.
• The Glucagon Renaissance in Obesity Therapeutics.

Food & Diet

• Association of Healthy Plant-Based Diet-Lifestyle Score with Obesity-Related Cancer Incidence and Mortality.
• Nutritional Strategies for Targeting Biological Age.
• A Series of N-Of-1 Dietary Intervention Studies with Whole-Grain Foods and Nuts Reveals Individual Predictors of Blood Pressure and Heart Rate.

Caloric and Dietary Restriction

• Caloric Restriction Suppresses Colorectal Tumors and Melanoma Through CD8 T Cells in Aged Mice.
• Intermittent Fasting Alleviates Neuropathic Pain and Cognitive Deficits Via an Alistipes Finegoldii-Hippuric Acid-STING Neuroimmune Axis.

Exercise & Physical Activity

• Associations of Dietary Patterns and Physical Activity with Body Composition in Healthcare Workers with Abdominal Obesity.
• Associations of Moderate-To-Vigorous Physical Activity with Obesity and Low Muscle Mass Among Postmenopausal Chinese Women: A Cross-Sectional Study.
• Increasing Skeletal Muscle Mass and Strength During Incretin-Based Weight Loss.

Economics & Sociology

• Prospective Annual Evaluation of Sports Motor Performance, BMI and Social Index in Swiss First Graders over a Period of 12 Years.
• Multidimensional Assessment of Women’s Nutritional Status and Empowerment in Peri-Urban Bengaluru.
• Adult Temporal Mobility (2002-2010) in Material Wealth and Physical Health, Self-Perceived Health, Sociality, and Use of Addictive Substances.

Epidemiology

• Transition from Preclinical Obesity to Clinical Obesity Among US Adults: Incidences and Risk Factors.
• Sex- and Age-Specific Associations between Body Composition Markers and Estimated Glomerular Filtration Rate - Results of a Population-Based Study.
• Modeling Pre-Pregnancy BMI as a Continuous Exposure for Obstetric and Neonatal Outcomes: A Population-Based Analysis of 3.4 Million Births.
• Time-Varying BMI, Waist Circumference and All-Cause Mortality in US Adults Aged 65 or Older.
• Temporal Association between Body Weight and Type 2 Diabetes at the Population Level.

Psychology & Neuroscience

• The Influence of Glucose Intake and Psychosocial Stress on Food Craving in Healthy Adults.
• Brain-Wide Activity Mapping Reveals the Somatosensory Cortex as a Sex-Specific Regulator of Hedonic Feeding.
• Does Flavor-Nutrient Learning Promote or Protect Against Diet-Induced Obesity? Individual Differences in Conditionability Predict Resistance to Weight Gain in Rats.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Variation in Obesity Burden, Multimorbidity, and Healthcare Costs Across Obesity Class, Sex, and Race/Ethnicity in the United States.
• Waist Circumference, Relative Fat Mass Index, and BMI as Classifiers of Diabetes Status: A Comparative, Cross-Sectional Analysis in 82 Low- and Middle-Income Countries.
• Ethnic Cardiovascular Disparities and Lipidomic Signatures in Chinese Children: Insights from a Historical National Survey and a Contemporary Regional Cohort.
• Ethnic Disparities in Cardiometabolic Health in Albania: Divergent Burdens Across Minority Groups.

Stigma

• Review: Beyond Weight: A Stigma-Free, Integrated Approach to Obesity in Patients Affected by Cancer.
• RCT: Compounding Stigma: Comparing Perceptions of an Individual Using Ozempic, Bariatric Surgery, or Behavior Modification.
• Weight Discrimination and Metabolic Syndrome: Examining Discrimination Attributions and Frequency Across Settings.

Policy Related

• Food Systems Performance Evaluated Against Targets and Benchmarks Reveals Urgent Gaps and a Path to 2050.
• Retrofitting Fiscal Policies to Reduce the Double Burden of Malnutrition in Peru.
• Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014-2026).
• Ultra-Processed Food (UPF) Consumption and Diet Quality Among Supplemental Nutrition Assistance Program (SNAP) Participating Adults.

Intergenerational Effects

• Association between Relative Cord Hyperleptinemia and Offspring Outcomes in Pregnant Women with Overweight or Obesity.
• Postpartum Glucose Follow-Up After Gestational Diabetes in China: Provider and Institutional Determinants in a Multicenter Survey Across Urban Public Hospitals.
• Multiple Generation Distinct Toxicant Exposures and Epigenetic Transgenerational Inheritance of Sex‑specific Outcross Impacts on Sperm Epigenetics and Obesity Pathology.
• A Placental and Fetal Liver TGFβ Signaling Axis Drives Fetal Immunosuppression in Maternal Obesity.
• Parental Obesity and Offspring Risk for Cardiorenal Diseases.

Ecology, Evolution, & Energetics

• A Bacterial Enzyme Enhances Both Energy Metabolism and Health Across the Life Span of C. Elegans and Mice.
• Effects of Time-Restricted Feeding on Health Outcomes: Lessons from Model Organisms.

Methods

• Ameliorative Effect of Rhus verniciflua Stokes on High-Fat Diet-Induced Obesity and Advanced Analysis with Machine Learning and Deep Learning-Based Network Pharmacology.
• Discrepancies between Caliper and Portable A-Mode Ultrasound Estimates of Subcutaneous Fat in Older Adults.

Commentary

• Gut Microbe Metabolite May Aid Malnutrition-Related Gut Damage.
• New Science on Early Life Biologic Markers for Obesity.
• Podcast: GLP-1s - From Gut Hormone Discovery to a Public Health Revolution a Healthy Dialogue with Jens Juul Holst and Lotte Bjerre Knudsen.
• Why Do People Eat Fad Diets?

General

• Survey: Regulatory Processes to Protect Researchers and Data.
• Measuring the Effects of Pharmacological Compounds on Mitochondrial Morphology in Mouse Aging Models.
• Review: A Conceptual and Methodological Exploration of Spin and Related Reporting Distortions in Dental Research.

Video & Audio

• Podcast: The Biggest Myth About Mitochondrial Health.
• Podcast: What Do People Eat? Plant and Animal DNA in Sewage Provide Clues.
• Podcast: Comparative Effectiveness of Global Well-Being Interventions.
• Podcast: Sleep, Hypertrophy, and Creatine.
• Podcast: Molecular Mechanisms of Colorectal Cancer Development.
• Podcast: Ancestry & Genetic Diversity in Human Fat Metabolism: Seed Oils & Omega Fats.
• Podcast: How Does Taste Work?
• Podcast: Do Microplastics in the Body Affect Pregnancy?

Announcements

• Arkansas Integrative Metabolic Research Center at U of A Awarded $11.2M Funding Round.
• The 5th Annual Kohlberg Johnson Family Human Milk Institute Symposium Is Closer Than You Think! March 9-11, 2027.
• Webinar: How Well Is the World Taxing Alcohol? Country Findings from the Inaugural Alcohol Tax Scorecard Date & Time Sep 3, 2026 08:00 AM in Central Time (US and Canada).