Obesity and Energetics Offerings

Featured

• Surprising Protein Links Dietary Restriction to Increased Lifespan in Flies.
• A Hypothalamic Neuronal Population Coordinates Metabolic Adaptations to Cold.
• Review: Creatine Monohydrate and Neuronal Methylation in Psychiatric Disorders.
• Podcast: New Study on Creatine During Fat Loss and Body Recomposition: Dr. Drew Gonzalez.
• Creatine for Glucagon-Like Peptide-1-Associated Muscle Loss.
• Is More Protein Always Better?

Headline vs Study

• Headline: Scientists Discover a Molecular "Memory" That Could Make Lost Weight Come Back.
• Press Release: Cleveland Research Team Identifies Biological Mechanism That May Explain Obesity Relapse.
• Study: Adipose TGFβ-Asprosin Memory Promotes Obesity Relapse and Offspring Obesity Susceptibility... In Mice and Cells.

Contrary or Null Findings

• RCT: "Twelve weeks of multispecies probiotic supplementation did not result in statistically significant improvements in glucose metabolism, insulin resistance, or lipid profile compared with placebo."
• RCT: "Heat-killed Bifidobacterium breve B-3 (B-3HK), a postbiotic, has shown muscle-related effects in preclinical studies...[but in this human RCT]...B-3HK did not improve muscle strength in patients with sarcopenia."
• Cold Water Dispersible Resveratrol Supplementation Does Not Alter Recovery Following Flywheel Squat Exercise.
• Nitrate Supplementation Does Not Improve Knee Extensor Fatigability and Exercise Hyperemia in Older Adults.
• When Fiber Does Not Protect: Evaluating Statistical Interaction between Dietary Fiber, Sodium-To-Potassium Ratio, and Metabolic Syndrome in South Korean Adults.
• Endurance Exercise-Induced Cardioprotection Against Metabolic Distress Does Not Require Body Weight Loss in Female Obese Type-2 Diabetic Mice.
• RCT: No Consistent support for primary hypotheses in "Effects of virtual reality-based aerobic exercise versus traditional aerobic exercise training on physical fitness, functional capacity, and quality of life in individuals with Down syndrome."
• Omega-3 Supplementation Modulates Whole-Blood EPA and DHA Without Improving Patient-Reported Outcomes in Youth with Migraine: A Quasi-Randomized Pilot Trial.

Basic

• Review: Cardiovascular-Kidney-Metabolic Syndrome as a Mitochondrial Systems Disorder.
• An RNA Thermogenic Therapy to Preserve Lean Mass and Enhance Metabolic Health During GLP-1 Weight Loss.
• IGF2BP3 Suppresses Adipogenesis Via M6A-Dependent Stabilization of FAM13A MRNA in 3T3-L1 Adipocytes.
• Inhibition of the Translin/Trax Complex by Ellagic Acid Alleviates Metabolic and Affective Behaviors in Obese Male Mice.
• Adipose ILC2s Depend on Acetyl-CoA Carboxylase 1 to Maintain Metabolic Health.

Scientific Rigor & Scholarly Dialogue

• PubPeer Comment: Efficacy of Faecal Microbiota Transplantation for the Treatment of Autism in Children: Meta-Analysis of Randomised Controlled Trials.
• Retraction: Efficacy of Faecal Microbiota Transplantation for the Treatment of Autism in Children: Meta-Analysis of Randomised Controlled Trials.
• Perspectives on the Protein Recommendations in the 2025-2030 Dietary Guidelines for Americans.
• Expert Reaction to Research Looking at Ultra-Processed Food, Physical Activity, Genetic Susceptibility and Type 2 Diabetes, Being Presented at the European Association for the Study of Diabetes (EASD) Conference in Milan.

Clinical

• Preclinical and First-In-Human Evaluation of Ribupatide (HRS9531), a Dual GLP-1/GIP Receptor Agonist.
• Review: The Intertwined Epidemics of Obesity and Obstructive Sleep Apnea: A Comprehensive Analysis.
• Decoding Obesity Through the Lens of Adipose Tissue Inflammatory Regulation: A Comparative Study of Obesity Subtypes.
• RCT: The Effect of an App-Based Nutritional Concept for Weight Reduction and Further Cardiovascular Risk Factors: Insights from the PreVA Study.

Children and Adolescents

• Association between Maternal Shift Work During Pregnancy Child Overweight and Metabolic Outcomes in Early Childhood.
• Knowledge, Attitudes, and Practices in the Management of Childhood and Adolescent Obesity: A Survey of Primary Care Providers in the State of Oklahoma, USA.
• Adiposity Trajectory as a Predictor of Chronic and Multisite Pain in the Transition from Childhood to Adolescence.
• RCT: Caregiver App Use and Child Behavioral Adherence in Relation to Obesity-Related Outcomes in an MHealth App-Assisted Childhood Obesity Intervention.
• Analysis of Factors Associated with Overweight and Obesity Among Preschool Children Based on a Decision Tree Model.
• Review: Diagnostic Approach to Genetic Obesity in Children: From Pathophysiology to Precision Medicine.

Surgery

• Meta-Analysis: The Effect of Bariatric Surgery on Ovarian Reserve Function in Women with Obesity.
• Survey: Morbid Obesity and Lower Limb Arthroplasty: Consultant Practice.
• Splanchnic Vein Thrombosis After Metabolic and Bariatric Surgery: Chilean Position Statement of Hepatology and Bariatric Surgery Societies.
• RCT: Sleeve Gastrectomy with Roux-En-Y Transit Bipartition Versus Sleeve Gastrectomy for the Treatment of Obesity and Reflux.
• Review: Prehabilitation for Patients Undergoing Breast Reduction Surgery.
• Meta-Analysis: Association between Metabolic and Bariatric Surgery and Melanoma Risk.
• Systematic Review: Impact of Surgical Weight Loss Interventions on Urinary Incontinence in Women with Obesity.

Drugs

• Review: GLP-1 Receptor Agonists, Gut Microbiota, and Chronic Pain: Nutritional Signaling at the Gut-Brain Axis.
• News: "Once described as obesity medicines for 'patients,' GLP-1s are increasingly lifestyle drugs for 'customers'."
• GLP-1 Receptor Agonist Coverage for Obesity in Medicaid and Total GLP-1 Receptor Agonist Utilization.
• Indirect Comparative Efficacy and Safety of Tirzepatide vs Semaglutide for the Treatment of Obesity or Overweight in Patients Without Type 2 Diabetes.
• Review: Recent Studies on the Effectiveness and Safety of Anti-Obesity Medications.

Food & Diet

• Meal Timing and Eating Window with All-Cause and Cardiovascular Mortality and Life Expectancy.
• News: Powered by Protein.
• Adherence and Weight Loss with a Total Diet Replacement Programme for Increased Cancer Risk Associated with Obesity: A UK Cohort Study.

Caloric and Dietary Restriction

• Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice.
• Mild Caloric Restriction Accelerates Atherosclerosis Via Dysregulated Cholesterol Homeostasis and Lipogenesis in HCHF-Fed ApoE-Deficient Mice.

Exercise & Physical Activity

• Leisure-Time Physical Activity and Metabolomic Trajectories over the Transition from Late Midlife to Old Age.
• Daily Physical Activity Behavior: A Compensatory Factor to Physical Adaptations Variability Following a 12-Week Power Training in Older Men.
• Effects of Creatine Supplementation with and without Exercise and Diet Intervention on Body Composition, Cognitive Function, and Markers of Health in Middle-Aged and Older Adults.
• Review: Effects of Aerobic Exercise-Based Interventions on Physical and Mental Health in Children and Adolescents with Overweight or Obesity: A Three-Level Meta-Analysis.

Economics & Sociology

• Systematic Review: Cost-Effectiveness Analyses of Weight Loss Interventions for Knee Osteoarthritis.
• Review: Economic Evaluations of Antiobesity Medications.
• Neighborhood Social Fragmentation and Excessive Body Weight Among Children-A View from a Portuguese Inner City.
• Social Physiology: Human Homeostasis Is More Efficient in Social Proximity.
• Review: Digital Health in Obesity Care: Current Evidence, Challenges, and Future Directions.

Epidemiology

• A Cohort Study of Physical Activity, Gut Microbiota, Serum Metabolites, and the Risk of Steatotic Liver Disease.
• Multidimensional Characteristics of Body Composition in Older Adults and Their Relationship to Common Chronic Diseases.
• Associations between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children.
• Report: State of Obesity Report 2026: Better Policies for a Healthier America.

Psychology & Neuroscience

• Family and Community Pressure, Obesity-Related Behaviours, and Psychological Well-Being Among Female Adolescents with Overweight or Obesity: A Qualitative Study.
• Obesity Modulates Mitochondrial Quality Control in Peripheral Blood Mononuclear Cells After Periodontal Treatment.
• Mitochondrial Dysfunction Markers in Paediatric Obesity: DNA Content and Oxidation Damage.
• Autophagy in Hypothalamic POMC and AgRP Neurons: Mechanisms and Therapeutic Implications for Obesity.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions.
• Systematic Review: Pharmacist Involvement in Overweight and Obesity Care: An Equity-Focused Systematic Review.
• Review: The Food Environment as a Cardiometabolic Exposure: Mechanisms, Inequities, and Interacting Environmental Risk.

Stigma

• Review: The Lived Experience of Children and Adults with Overweight or Obesity Engaging in Weight Management Treatments.
• Approaches to Obesity Among Adults with Accurate Body-Size Perception.

Policy Related

• Review: Toward International Dietary Guidance: A Food Guide Pyramid for Human and Planetary Health.
• Commentary: Precision Nutrition Testing Is the Future of Personalized Care: Evidence and Coverage Policies for Equitable Access.
• Remote Services, Benefits, and Program Retention Changes Among Young Children in WIC.
• Systematic Review: Nutrient Profile Models for Front-Of-Pack Nutrition Labelling.
• Systematic Review: Corporate Political Activity and Evidence of Policy Capture in National Obesity Prevention Policies (2000-2025).

Intergenerational Effects

• A Metabolic-Epigenetic Switch Governs Multicellular Cardiac Repair Following Succinate Dehydrogenase Inhibition.
• Associations between Maternal and Cord Blood Leptin Levels and Anthropometry of Mothers and Infants.
• Differential Methylation at Novel Putative Imprinting Control Regions on Chromosome 20 Associated with Childhood Obesity.

Ecology, Evolution, & Energetics

• Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity.
• Resting Energetic Adaptations over the Course of a 10-Month Multidisciplinary Weight Loss Intervention in Adolescents with Obesity: The POWELL-2 Project.
• Early-Life Cardiovascular Programming by Maternal Protein Restriction: Electrophysiological, Structural, and Molecular Alterations in Female Rats.
• Pharmacological Investigation of Beauvericin in High-Fat Diet-Induced Obesity in Rats.

Methods

• Deep Learning from Retinal Images for Prediction of Biomarker-Informed Obesity Subtypes Associated with Cardiometabolic Risk.
• Study of the Genetic Basis of Childhood and Adolescent Obesity with Stress Through the Analysis of Multidimensional Data with Machine Learning and Artificial Intelligence Tools.
• Review: Artificial Intelligence in Obesity Management: Clinical Evidence, Translational Gaps, and Implementation Priorities.

Commentary

• Podcast: The Mortality Effect of Walnuts are Hard to Ignore - Why?
• Podcast: Abbey Sharp Dissects Claims Regarding Saturated Fat & Health.
• Podcast: Heat After Lifting: Better Muscle Growth or Strength? With Aidan Hopper.
• Podcast: Can Creatine Keep Your Brain Sharp After a Sleepless Night? | Dr Ali Gordji-Nejad.
• Review: Why Exercise Does Not Work Equally Well for Everyone: Life-Course Conditions and the Limits of Precision Medicine.
• Podcast: How Much Should You Eat on a Bulk?
• Life and Death: Ultra-Processed Foods Linked to Everything.
• What Do REIMAGINE 5 Toplines Suggest About CagriSema?
• Obesity Science's Fat-Cell Blind Spot.

General

• INSPECT-SR Tool for Assessing Trustworthiness of RCTs.
• Podcast: "Many of us assume that we are visual learners, or we learn by doing or by seeing something on the printed page. ... But it's complete pseudoscience" according to [Dean of Education] Katie Dyer.
• Podcast: Is Moderate Drinking Actually Healthy?
• An Assessment of Data and Code Sharing in Research Funded by the Nathan Shock Centers, 2017-2022: A Meta-Research Study.
• MTORC1-TFEB/TFE3 Signaling Is Associated with Bile Acid Diversification During Hepatic Metabolic Adaptation.
• Diabetes Technology in the School Setting for Preschool-Aged Children.
• Insulin Resistance After Cardiac Arrest: More Than a Glucose Problem.

Announcements

• Measuring Energy Metabolism Across the Epidemiologic Transition.

Featured

• Preferences for Obesity Medications Among People with Overweight or Obesity in the United States: A Discrete-Choice Experiment (OPTIC).
• Podcast: Food Noise Is Real, and Now We Can Measure It.
• RCT: Effects of Full-Fat and Low-Fat Fermented Dairy Foods on Markers of Cardiometabolic Health in Adults with Overweight or Obesity and Elevated Fasting Triglycerides.
• Meta-Analysis of RCTs: Impact of Milk Fat Globule Membrane and Its Associated Polar Lipids on Markers of Cardiometabolic Disease and Cognitive Function.

Headline vs Study

• Headline: Eating More Ultra-Processed Foods Linked to Worse Health, Study Finds.
• Press Release: Higher Ultra-Processed Food Intake Linked to Multiple Health Risks.
• Meta-Analysis of Observational Studies: Ultra-processed food and risk of multiple chronic diseases: "all studies relied on self-reported dietary assessments, which may not fully capture processing characteristics, ingredient composition, or UPF subtypes, leading to exposure misclassification and measurement error..."

Contrary or Null Findings

• "Contrary to our expectations, Necturus exhibited both absolutely and relatively larger jaw muscles than Salamandra and produced higher bite forces, even when scaled to the same size."
• "Contrary to hypothesis, NH and CB produced different metabolic responses despite reducing peripheral oxygen saturation."
• "Contrary to the prevailing view that brain L-serine is exclusively derived from de novo synthesis, we demonstrate that dietary L-serine is required to maintain brain L-serine levels and prevents the formation of neurotoxic 1-deoxysphingolipids."
• "Contrary to the conventional view that mtDNA damage is solely detrimental, we find that NTHL1 loss confers a beneficial, mitochondria-initiated phenotype in human cells."
• "Intriguingly, contrary to earlier literature, we detected elevated α-SMA expression upon BBR [berberine] treatment despite the suppression of cell migration, proliferation and collagen production."
• "Contrary to our predictions, circulating PYY concentrations did not increase following feeding, did not significantly differ between food-restricted and ad libitum birds, and were unrelated to either feeding latency or food consumption. Collectively, these findings fail to support the hypothesis that PYY functions as a conserved short-term satiety signal in zebra finches."
• "Contrary to expectations, urbanicity did not moderate the association between income and outdoor play."
• No Effect of Acknowledging Resistance or Using Autonomy-Supportive Language in Vlogs on Sustainable [Non-Meat] Consumption Intentions of Emerging Adults.

Basic

• Adipose Tissue Plays a Crucial Role in Obesity-Induced Postoperative Neurocognitive Disorders.
• Glucocorticoid Receptor Signaling Protects Human Mature Adipocytes from Metabolic Stress and Is Impaired in Obesity.
• Early Life High-Fat Diet Exposure Modulates Adult Metabolic Phenotypes in Drosophila.
• High-Swelling Edible Cellulose-Based Hydrogel for Gastric Filling and Satiety Induction.
• Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 Signaling Pathway in HGI C. Elegans.
• Obesity Increases Atherosclerosis Susceptibility Via an Intertissue MiR-30e-SLC7A11 Axis.
• Hyodeoxycholic Acid Suppresses Hepatic Steatosis in a PPARα-Dependent Manner Via Distinct GLP-1- and INKT Cell-Mediated Pathways.

Scientific Rigor & Scholarly Dialogue

• Preprint: Quantifying Evidential Rigor in Meta-Analytic Corpora: A Simulation-Characterized, Bias-Robust Bayesian Workflow with a Nutrition Case Study.
• Dietary Intake as an Undermeasured Potential Mediator: The Ethical Case for Complete and Transparent Dietary Reporting in GLP-1 Receptor Agonist Trials.
• Expert Reaction to UPF Consumption Linked to Higher Risk of Multiple Chronic Diseases.

Clinical

• The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain.
• RCT: Effects of a Self-Selected Vegetarian Vs. Omnivorous Diet on Protein Intake and Muscle Mass in Older Adults During Resistance Exercise.
• RCT: Declines in Plasma Erythritol and Improvements in Cardiovascular Risk and Atherogenic Lipid Profiles.
• Review: Obesity and Pelvic Organ Prolapse.

Children and Adolescents

• Motor Competence and Components of Metabolic Syndrome in Children and Adolescents with Overweight and Obesity.
• The Temporal Relationship Among Socioeconomic Vulnerability, Dietary Intake, and Childhood Obesity Across Six European Countries.
• Meta-Analysis: Association of Adverse Childhood Experiences and Overweight or Obesity in Adolescents.
• Meta-Analysis: Association between Overweight/Obesity with Depression, Anxiety, Low Self-Esteem, and Body Dissatisfaction in Children and Adolescents.
• Review: Adolescent Obesity: A Stepwise Clinical Approach.

Surgery

• Sentinel Lymph Node Mapping Versus Systematic Lymphadenectomy in Women with Obesity Undergoing Minimally Invasive Surgery for Endometrial Cancer.
• Comparative Analysis of Different Modifications of the Caprini Risk Score in Bariatric Surgery.
• Preprint: Efficacy and Safety of Employing an Intragastric Balloon to Manage Super Obesity, Either as a Standalone Treatment or in Combination with GLP-1 Receptor Agonists.
• RCT: Diabetes Remission 10 Years After Bariatric Surgery: Extension Study.
• Beyond Age and Comorbidities: Frailty and Cognitive Impairment are Associated with Early Medical Complications After Surgery for Lumbar Spinal Stenosis in Patients Aged 75 Years and Older.

Drugs

• Commentary: Tirzepatide for OSA and Obesity: Do We Know the Effect on Cardiometabolic Outcome?
• Interpretation of World Health Organization Guideline on Glucagon-Like Peptide-1 Therapies for Obesity in Adults.
• Targeting the Cardiohepatic-Metabolic Axis: GLP-1-Based and Incretin Multi-Agonist Therapies in MASH.

Food & Diet

• Intermittent Fasting Modulates Immune Signatures but Not TNF-Dependent Pathology in Mice with Constitutive STING Activation.
• Balancing Metabolism-Control of Weight Gain, Blood Glucose Levels and Intestinal Leakiness by Alpha-Lactalbumin-Oleic Acid Complexes.
• RCT: A Higher-Complex Carbohydrate vs Conventional Low-Carbohydrate Diet in Gestational Diabetes Mellitus Results in Lower Postprandial Free Fatty Acids.
• The Impact of Obesity on Appetite Regulation During Nutritional Ketosis.

Caloric and Dietary Restriction

• Diet-Responsive Proteogenomic Effects Following Short-Term Restriction of Animal Products in Humans.
• Direct Comparison of Serine Restriction on the Viability of Normal and Cancer Cells Demonstrates That Methionine Restriction Is More Cancer Specific.
• Impact of Caloric Restriction on Biological Aging: Insights from a Composite Biomarker Index in Older Adults.

Exercise & Physical Activity

• Meta-analysis: Physical Activity and Oxidative Stress Biomarkers in Humans.
• RCT: The Impact of a Lifestyle Intervention on Postpartum Physical Activity Among Predominantly Puerto Rican Women with Overweight and Obesity: Proyecto Mamá.

Economics & Sociology

• Association between Parental Socioeconomic Characteristics and Overweight and Obesity Among Adolescents.
• Associations of Work-Related Extended Availability with Overweight and Obesity Among Chinese Workers.
• Cardiometabolic Health in P'urépecha Migrant-Sending Communities in Michoacan, Mexico.
• Systematic Review: Co-Ethnic Exposure and Cardiometabolic Outcomes in Racial and Ethnic Minoritized Populations.
• County-Level Food-Related Implicit Associations, Socioeconomic Factors, Food Environment, and Health Outcomes.
• Dissertation: Insulin Resistance from the Inside Out: The Effect of Physiological and Neighborhood Factors on Insulin Resistance in Individuals with Overweight and Obesity.
• Socioeconomic Determinants Associated with Overweight and Obesity in Adults in Southern Tehran.

Epidemiology

• Population Burden of Diabetes, Hypertension, and Cardiovascular Disease Attributable to Obesity: A Community-Based Study in Türkiye.
• Obesity and Poor Sleep Quality - Prevalences and Risk Factors.
• Obesity and Outcomes After Esophagectomy.
• Associations of Body Fat Percentage-Based Obesity with Depression and Comorbidity-Related Gut Microbiota Features in College Students.
• Adiposity and Infection-Related Mortality: Mendelian Randomization Study of 126 000 Mexican Adults.
• Differential Expression of Human and Bacterial Proteins Reveals Microbiome-Host Crosstalk in Metabolic Disorders.
• A Landscape of Metabolic Burden and Its Cardiovascular Impact Across the Adult Lifespan.

Psychology & Neuroscience

• Genome-Wide Association Meta-Analysis of Eating Behavior Traits Revealed One Susceptibility Locus for Emotional Eating.
• Meta-Analysis: BMI and Regional Brain N-Acetylaspartate.
• What are the Experiences, Perceptions and Expressed Needs of Adolescents Living with Obesity and Their Mothers in Indonesia?
• Diet and Physical Activity Profiles Among College Students: Associations with Alcohol Use and 'Better for You' Product Choices.
• Dynamic Remodeling of Dentate Gyrus Microglia Underlies Adult Depression-Like Outcomes Following Adolescent High-Fat Diet Exposure.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Preprint: Cardiometabolic Dysregulation and the Social Determinants of Health in a Food Insecure Population.
• Dissertation: Early-Life Socioeconomic Disadvantage, Domain-Specific Self-Regulation, and Pediatric Obesity Risk.

Ethics

• Ethical Dimensions of Bariatric Surgery: A Narrative Review of Principles, Challenges, and Practice Implications.

Stigma

• Weight Stigma, Body Trust, and Suicide Ideation Among Adolescents: A Longitudinal Study.
• A Two-Way Street? Examining Nurses' Personal Experiences of Weight Bias in Clinical Settings.

Policy Related

• The Retail Food Environment Following a Mandatory Healthy Checkout Policy: A Natural Experimental Evaluation.
• Infant Diet Quality and Federal Nutrition Assistance Program Participation Predict Later Diet Quality in U.S. Children 2-5 Years Old.

Intergenerational Effects

• Asparaginase Methylation and Childhood Obesity.
• In-Utero Exposure to Maternal Hyperinsulinemia Impacts Glucose Homeostasis in Male Offspring Transiently.

Ecology, Evolution, & Energetics

• Impact of Meal Caloric Content on the Thermic Effect of Food in Adolescents with Obesity.
• Phosphodiesterase 4 Inhibition Attenuates Diet-Induced Obesity and Activates BAT Thermogenic Pathways Through Central Mechanisms.

Methods

• Discordance between BMI-Defined Overweight/Obesity and Waist-To-Height Ratio-Defined Central Obesity Among Adults with Type 2 Diabetes in Malawi.
• Causal Adiposity and Clinical Validation of Regional Fat Distribution in PMOS: A Multi-Modal Analysis Integrating GBD 2021, Mendelian Randomization, and Machine Learning.
• Longitudinal Validation of an Original Bias-Reduced Fat-Free Mass Metabolic Coefficient in Inpatients with Obesity.

Commentary

• Podcast: Expert Misinformation Online/Experts Correcting Experts? ROUNDTABLE.
• An Experiment to Explain the Success of Wegovy Tablets.
• Are GLP-1s Changing the Equation for Food Marketing?
• Human Milk as a Model for Next-Generation Infant Formula: Opportunities and Challenges.
• The Unique Metabolic Signature of Obesity and Stress.
• Health Benefits of Sardines.
• A Single RNA Shot Cut Visceral Fat 14% Without Muscle Loss.
• Podcast: "What if some of what we still teach about breast anatomy, milk supply, pumping, and milk ejection is based on an outdated understanding of how the lactating breast actually works?"

General

• Podcast: Do Lemmings Really Jump Off Cliffs?
• RCT: Effects of Acute Low-And Moderate-Dose Alcohol on Chronic Disease-Related Biomarkers in Healthy Light and Heavy Drinkers.
• "Contrary to general expectation, these findings indicate that fixed phone boxes do not reliably reduce suicide mortality, with two sites even showing increased rates after installation."
• 'Momnesia' Is Real - Scientists Find a Biological Explanation for Temporary Forgetfulness During Pregnancy.
• Phylogenomics and Museomics Reveal Five Distinct Species of Tiger Cats in South America.

Video & Audio

• Elizabeth McDonald, MD, PhD, on GLP-1 Agonists and Breast Cancer Incidence.

Announcements

• USDA's Operation SNAP Back Hits the Five Boroughs.

Featured

• RCT: Effect of Diet Macronutrient Content on the Cardiometabolic Response to Weight Loss.
• Adipose TGFβ-Asprosin Memory Promotes Obesity Relapse & Offspring Obesity Susceptibility.
• Psychometric Properties of a Fathers' Outcome Expectancies of Lifestyle Behaviors Instrument for Father-Child Reciprocal Reinforcement.
• ALKBH5 Activates Creatine-Driven Thermogenesis by Stabilizing CKB MRNA in Response to Cold.

Headline vs Study

• Headline: Are Vegans Hotter Than Meat Eaters? Experts Say Yes - in Three, Key Ways.
• Headline: Plant-Based Diets Could Help You Achieve Peak Physical Attractiveness, Scientists Say.
• Study: Narrative review of "plant-forward" diets (not necessarily vegan) and select measures of attractiveness. "...the selection process carries a risk of confirmation bias toward studies supporting the primary hypotheses."

Contrary or Null Findings

• RCT: "A self-selected vegan diet reduces protein intake, skeletal muscle mass, and MPS [muscle protein synthesis] in older adults" in "A self-selected vegan diet reduces skeletal muscle mass in healthy older adults."
• "Medicare Advantage was not associated with lower hemoglobin A1c, systolic or diastolic blood pressure, low-density lipoprotein cholesterol, or lower risk of food, housing, and transportation needs."
• RCT: "Although lower Lp(a) levels were observed with pelacarsen, the findings did not demonstrate that this translated into reduced cardiovascular risk in the overall study population."
• "Serum vitamin A and E concentrations in neonatal intensive care infants did not consistently reflect intakes" in "Associations between intake of vitamins E and A and serum concentrations in preterm infants."
• European Trials Find Non-Nutritive Sweeteners Do Not Undermine Weight Loss.
• RCT: "Overall, probiotic supplementation of S. boulardii in PCOS women did not affect weight, BMI, or FBS..."
• RCT: "UPF restriction did not result in significantly higher post-intervention [Highly Processed Food Withdrawal Scale] scores compared with generic energy restriction in free-living individuals with obesity..."
• RCT: "Moderate protein restriction does not increase basal autophagy in circulating immune cells of healthy adults, suggesting protein reduction alone, without caloric deficit, may be insufficient to activate autophagy in human blood."

Basic

• Obesogenic Diet Impairs Social Memory Through Alterations of Hippocampal CA2 Excitability and Oxytocin Signaling.
• Interleukin-4-Loaded Lipid Nanoparticles Reprogram Adipose Tissue Immunity and Promote Adipocyte Browning for the Treatment of Obesity.
• N-Terminal Thrombospondin-1 Enhances Muscle Function and Tissue-Specific Metabolic Adaptation in Response to Exercise and Cold Exposure.
• Adipose Tissue Remodeling Beyond Weight Loss: New Insights Into Incretin-Based Therapies and Bariatric Surgery.
• Review: The Gut Microbiome-Cardiometabolic Axis: Insights Into Obesity, Type 2 Diabetes, and Hypertension.
• Adipocyte-Specific Deletion of Adrenomedullin Exacerbates High-Fat Diet-Induced Hypertension.
• Increased Energy Expenditure Through Intermittent Cold Exposure Does Not Enhance Tirzepatide Induced Weight-Loss in Obese Mice.

Scientific Rigor & Scholarly Dialogue

• Audit of Abdelbasset et al. (2019): Three Randomized Controlled Trials on Exercise and Depression.
• Corrigendum: Does Severe Obesity Define a Threshold over Which Robotic Sentinel Lymph Node Mapping Outperforms Laparoscopic Mapping in Endometrial Cancer?
• No, Those Raspberries Didn't Cut Your Risk of Death by 14%.
• Retraction: Protective Effects of Calorie Restriction and 17-β Estradiol on Cardiac Hypertrophy in Ovariectomized Obese Rats.

Clinical

• Why Do We Lose Bone During Weight Loss: Can It Be Prevented?
• Social Support and Perceived Dietary Barriers Mediate Weight Loss in the AMPLIFY Web-Based Diet Intervention.
• Generative AI: Digital Health in Obesity Care: Current Evidence, Challenges, and Future Directions.
• A Comprehensive Obesity Benefit: Guidance for Occupational and Environmental Medicine Professionals.

Children and Adolescents

• Physician-Related Predictors of Referral for Multidisciplinary Paediatric Obesity Management: A Population-Based Study.
• Meta-Analysis: Mindfulness-Based Interventions for Improvement of Lifestyle Behaviors and BMI in Children with Overweight or Obesity.
• One in Four Children Experience BMI Increase After Lower Extremity Surgery Without Return to Preoperative Levels.
• Comparing Two Diagnostic Frameworks for Obesity in Mexican Children Attending a Pediatric Obesity Clinic.

Surgery

• Review: Adipose Tissue Remodeling Beyond Weight Loss: New Insights Into Incretin-Based Therapies and Bariatric Surgery.
• Cohort Study: Associations between Obesity Phenotypes Defined by BMI and Waist Circumference with Postoperative Complications and Mortality.
• Observational Study: Comparative Evaluation of Sternomental and Hyomental Distance-Based Dynamic Airway Indices for Predicting Difficult Laryngoscopy in Surgical Patients with Obesity.
• Cohort Study: Abdominal Compartment Syndrome Following Major Abdominal Surgery.
• Retrospective Study: Association between BMI and Two-Year Clinical Outcomes Following Surgical Treatment of Insertional Achilles Tendinopathy.
• Where Does Surgery Fit in the Era of Effective Obesity Pharmacotherapy? Positioning Metabolic Bariatric Surgery Within Multimodal Obesity Care.

Drugs

• Scientific Statement: Obesity Science, Research Gaps, and Opportunities in the New Era of Obesity Medicines: an Endocrine Society Scientific Statement.
• RCT: Safety, Pharmacokinetics and Pharmacodynamics of the GLP-1/GIP/GCG Receptor Agonist UBT251 Injection.
• Meta-Analysis of RCTs: Tirzepatide and the Incidence of Atrial Fibrillation in Adults with Overweight or Obesity.
• Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity.
• Females are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.
• Nationwide Real-World Retrospective Study of Oral Semaglutide Use in Adults Living with Type 2 Diabetes in Finland.

Food & Diet

• Reductions in Sugar-Sweetened Beverage Intake and Weight are Maintained Following a Digital Health Intervention.
• Does Protein Source Influence Ageing Muscle? A Contemporary Physiological Perspective.
• RCT: Sweet Relief: Effectiveness of Dark Chocolate for Managing Menstrual Cycle-Related Symptoms in Female Athletes.
• Review: Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies.

Caloric and Dietary Restriction

• Beyond Weight Loss: Disentangling the Direct Effects of Semaglutide vs Equivalent Calorie Restriction on Reproductive Systems of Male and Female Rats.
• Caloric Restriction Modulates Genome-Wide Somatic Mutation in Mice.
• Influence of Different Degrees of Food Restriction on Immune Function and Gut Microbiota in Brandt's Voles.

Exercise & Physical Activity

• Comparative Effectiveness of Aerobic Exercise Versus Resistance Training on Cardiometabolic Health in Patients with Diabesity.
• Systematic Review: Exercise Modalities for Adults with Type 2 Diabetes Mellitus and Obesity: Comparative Effects on Visceral Fat, Metabolism, and Inflammatory Markers.
• RCT: Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults with Obesity.
• RCT: Acute Appetite and Gut-Hormone Responses to Two Combined Training Sessions in Men with Obesity.
• Secular Trends in Physical Fitness and Nutritional Status Among Tibetan Children and Adolescents from 2005 to 2019.

Economics & Sociology

• Heterogeneous Effects of Working Time Reduction on Overweight: Evidence from France.
• Association between Mukbang and Cookbang Watching and Obesity in Korean Adolescents.
• Lifestyle Intervention Powered by Sport Fandom in Men with Overweight or Obesity: A 1-Year Cost-Effectiveness Analysis of the Hockey FIT Trial.
• Cost-Effectiveness of Access to Obesity Care and Treatments for Adolescents.
• Medical Expenditures by BMI Among Privately Insured US Adults Aged 18 to 64 Years, 2022.
• Cost-Effectiveness of Semaglutide 2.4 mg for Obesity Disease Management in Japan: A Lifetime Economic Modeling Study Incorporating Retreatment Scenarios.
• Abstract: Does Living with Obesity During Tertiary Education Affect Employment Outcomes After Graduation? Longitudinal Evidence on 1,673 Young Adults in China.
• Association of BMI Categories with Healthcare Use and Health Expenditures in Switzerland.
• Clinical and Economic Burden of Obesity and Cardiovascular Disease Among Medicare Fee-For-Service Beneficiaries.

Epidemiology

• Redefining Obesity Risk for Heart Failure: Incorporating Morbidity Into the 2024 EASO [European Association for the Study of Obesity] Framework Definition of Obesity.
• Clinician Counseling and Weight Loss Attempts Among Survivors of Obesity-Associated Cancers.
• Characteristics of Patients with Acute Respiratory Failure in Obesity Hypoventilation Syndrome in the Intensive Care Unit.
• Meta-Analysis: Global Prevalence of Sarcopenic Obesity Defined by European Society for Clinical Nutrition and Metabolism/European Association for the Study of Obesity Criteria.
• Prepregnancy BMI, Pregnancy Physical Activity Trajectories, and Postpartum Blood Pressure.
• Review: Adverse Outcomes of Sarcopenic Obesity in Older Adults.
• Cohort Study: Follow-Up Longitudinal Observational Study on Risk Factors and Health in Adults.
• Diagnostic Variability in Sarcopenia and Sarcopenic Obesity Among Older Adults: A Clinical and Public Health Challenge.

Psychology & Neuroscience

• Psychological Characteristics of Patients from Obesity Treatment Program in Gdańsk.
• Cross-Sectional Study: Physical Activity Moderates Links between Weight Misperception and Adolescent Mental Wellbeing.
• "My Body Is Weary from Weight, My Mind from Criticism" Experiences of Women Living with Obesity in Turkiye.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Weighed Down by Paperwork: Identifying Barriers to Metabolic and Bariatric Surgery Evaluation in the United States.
• Cohort Study: Whole-Population Trends in Obesity Across Dimensions of Inequality in England, 2019-25.
• Cohort Study: Sociodemographic and Socioeconomic Differences in the Use of Anti-Obesity Medications.
• Systematic Review: Socioeconomic Inequalities in Exposure to Neighborhood Food Environments.
• Obesity and Food Insecurity Among College Students in the Alabama Blackbelt.

Stigma

• The Role of Shame and Self-Esteem in the Relationship between Internalized Health-Related Stigma and Mental Health Symptoms in Adults with Chronic Health Conditions.
• Weight Discrimination and Disordered Eating Behaviors Among Young Adults with High Weight Status.
• Associations between Specific Forms of Teasing and Body Image Dissatisfaction in Adolescents.

Policy Related

• Steering Biofortification of Zn, Fe and Se in Staple Cereals (Wheat, Maize and Rice) for Micronutrient Hunger Mitigation: From Trials to Industrialized Food Products.
• Report: Food as Medicine in Los Angeles County: Policy and Practice Insights 2025.
• Exploring the Practices of Healthcare Practitioners During the Implementation of a Healthy Eating Policy.

Intergenerational Effects

• Gestational Weight Loss Relative to Prepregnancy Weight in Women with Gestational Diabetes: Impact on Maternal and Neonatal Outcomes.
• Influence of Maternal Obesity, Gestational Weight Gain and Gestational Diabetes on Child Metabolic Profile: A Prospective Study from the Intrauterine Period Until Early Childhood.

Ecology, Evolution, & Energetics

• Early-Life Environment Drives Long-Term Decrease in Adult Body Mass in a Wild Bird Population.
• Evolutionary Mismatch between Stomach Capacity and Modern Diets: Implications for Obesity and Metabolic Disease.
• Integrated Transcriptomic Analysis of MRNA and miRNA in Brown Adipose Tissue of the Greater Horseshoe Bats During Hibernation.
• Fine-Scale Body Condition Dynamics in Elk Revealed by Implanted Bioimpedance Biologgers.

Methods

• Obesity Definition by Percentage of Body Fat Compared to BMI in a Kidney Transplant Transition Clinic.
• Preprint: Reclassification of Hypertension Risk Using an Adiposity-Based Obesity Definition in Two Prospective Cohorts.
• Validity and Utility of Self-Reported Weight Gain Since Age 20 in a 30-Year-Old Japanese Working Population.

Commentary

• Podcast: "We also consider the broader implications for the use of processing-based classifications in nutrition science and whether this adds meaningful explanatory value beyond traditional assessments of diet quality."
• Podcast: More Coffee or Better Focus? The Surprising Science of Caffeine & Breathing | Dr Sedat Arslan.
• Women Who Ate More Antioxidants Had Strikingly Lower Rates of Cervical Cancer.
• Podcast: Physionic rebuts claim that "Fiber's Health Benefits are Built on FLAWED Research."
• Podcast: Metabolic Effects of Diet Composition on Weight Loss Outcomes.
• Sanctimonious Food Policy Won't Help.
• Is Sugar Toxic? Can It Cause Cancer? Gary Taubes.

General

• Disruption of the Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans Dramatically Increases Male Longevity and Enhances Reproductive Health Late in Life.
• When Wine Walked Into Grocery Stores: Examining the (Un)intended Economic Consequences of Wine Sale Reform in Tennessee.
• Editorial: The World Bank is right to prioritize reproducibility: The development bank and others are starting to publish and verify the raw data and code accompanying their research-based reports and papers. Other agencies should do the same.
• Understanding NIH's Unified Funding Strategy: What the Research Community Needs to Know.
• Highly Potent Compound Blocks Ebola Virus Infection and Improves Survival in Animal Model.
• Effects of a Reintroduced Tiger Population on Large Carnivores in Panna Tiger Reserve, Central India.
• Preprint: Dietary Traits, Systemic Inflammatory Proxies, and Insomnia-Related Outcomes: Exploratory Mendelian Randomization and Population-Based Evidence.

Announcements

• "Balas has been conducting research on research for more than a decade, and the grant from NIH's National Institute of General Medical Sciences will allow his team to create a database consisting of prevalent research defects and develop prevention measures that researchers can use to ensure their studies are accurate and reproducible."
• 2026 Gill Symposium to Honor Leading Researchers Behind GLP-1 and Incretin Biology Breakthroughs.
• Webinar: Microplastics Analysis in Food: Current Challenges & Opportunities for Standardization. September 22, 2026.
• Arkansas Children's Hospital Nationally Ranked in 9 Specialties, 1st in Arkansas, and 2nd in Southeast Region, by US News and World Report.

Featured

• Ultra-Wideband Radar to Measure in Vivo Muscle Forces.
• Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship between Potatoes & Colorectal Cancer.
• Preprint: The Energetic Cost of Building Human Skeletal Muscle.
• Preprint: Across 5 European Countries Poodles and Poodle Crosses are "Fussy Eaters" Whereas Labradors "Eat Anything" Compared to Other Breeds and Their Crosses: Results from a Dataset of over 615,000 Canine Records.

Headline vs Study

• Headline: Ozempic Supera Al Ayuno Intermitente: El Fármaco Ayuda Más a Frenar El Envejecimiento (Ozempic Outperforms Intermittent Fasting: The Drug Is More Effective at Slowing Aging).
• Press Release: GLP-1 Treatment Late in Life Extends Lifespan in Animal Model.
• Study: Late-Life Semaglutide Treatment Slows Ageing and Extends Lifespan in Female Mice.

Contrary or Null Findings

• Meta-Analysis: "... the available evidence does not indicate a clear overall advantage of morning over evening/nighttime exercise for most sleep outcomes." in "Effects of morning versus evening exercise on sleep."
• RCT: "At 12 months, the weight loss was -2.5% in the intensive group [frequent nutritional guidance, enhanced diet and exercise therapy, and additional pharmacotherapy] and -1.7% in the standard group, with no significant difference in the primary outcome."
• RCT: Maternal High-Protein/Low-Glycemic-Index Diet During Pregnancy Impairs Offspring Lipid Profile.
• RCT: "A 16-week supervised concurrent exercise program initiated ~ 10 days after bariatric surgery did not improve weight loss compared with usual care."
• RCT: "In GI cancer patients undergoing major abdominal surgery, early SPN [supplemental parenteral nutrition] showed no significant difference in 5-year [overall survival] compared with late SPN. The findings do not support the use of early SPN to improve long-term survival in this patient population."
• RCT: Individualized Targeted Exclusion Diet Based on Confocal Laser Endomicroscopy Does Not Improve Irritable Bowel Syndrome Symptoms.
• Meta-Analysis: "ESG [Endoscopic sleeve gastroplasty] combined with [anti-obesity medications] may enhance early weight loss in selected settings; however, current evidence does not support consistent long-term superiority over ESG alone for weight or glycemic outcomes."
• "BMI has little impact on the EE [energy expenditure] of walking at speeds between 0.89 m/s and 1.79 m/s, and that sex differences in walking EE are eliminated after controlling for height."
• RCT: "There was no difference in [body weight] between Fx [whole fruit feijoa powder] and Placebo over the 6-month intervention. [Fasting plasma glucose] followed the weight loss trajectory in both treatment groups, but with no between-group interaction over 6 months."

Basic

• Review: Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.
• Neutrophil Serine Proteases Inhibit Thermogenic Capacity of Visceral White Adipose Tissue.
• POMC AMPKα1 Deletion Drives Male-Specific BAT Thermogenesis and Obesity Resistance.
• Photic Cycle Shorter Than or Equal to Endogenous Tau Postpones Diet-Induced Obesity in Mice and Shows a Robust Aftereffect.
• Macrophage IgG Recycling Couples Glomerular IgG Accumulation to Podocyte Senescence in Obesity-Related Glomerulopathy.
• Statins Promote Muscle Metabolic Danger and NLRP3-Mediated Myopathy Via Lower Protein-Prenylation and YAP.
• Weight Loss Without Food Intake Suppression Through Size-Dependent Retention of Anti-Inflammatory Nanomedicines.
• Exosome Trafficking Is a Key Regulator of Adipocyte Thermogenesis.

Scientific Rigor & Scholarly Dialogue

• The 109 Percent Problem: What a Flawed Obesity Study Can Teach Us About the Premier League. (pdf)
• Podcast: Is Obesity a Muscle Problem?
• Podcast: Physionic's Nicolas Verhoeven Critically Examines the Evidence for Some Counter-Conventional Thinking on Dietary Fatty Acids and LDL Cholesterol.

Clinical

• Clinical Obesity Beyond BMI Identifies a Large High-Risk Subgroup in UK Adults.
• Meta-Analysis: Effectiveness of Mobile Application-Based Multimodal Behavioral Interventions on Weight Loss in Obesity.
• Meta-Analysis: Treatment Strategies for Functional Hypogonadism in Men with Obesity.
• RCT: Lactococcus lactis Subsp. lactis CAB701 Reduces Body Fat Mass in Adults with Overweight or Obesity.

Children and Adolescents

• RCT: Family-Centered Child Obesity Treatment.
• Trends in GLP-1 Receptor Agonist Prescriptions for Children Ages 8 to 11 with Obesity: 2019-2026.
• Systematic Review: Associations of Sugar-Related Food Parenting Practices and Parental Feeding Styles with Prospective Dietary Behavior of Children and Adolescents.
• Unhealthy Food Television Advertising and Body Weight in Mexican Children.
• Obesity and Severe Obesity Prevalence Among Youth Aged 2-17 in Minnesota, 2020-2025.
• Quantification of Appetite-Regulating Hormones in Children with Hypothalamic and Common Obesity.
• Preprint: Genetic and Behavioural Architecture of Childhood Eating Behaviour and Links to Obesity Risk.
• Comparing Two Diagnostic Frameworks for Obesity in Mexican Children Attending a Pediatric Obesity Clinic.

Surgery

• Excess-Weight Metrics Misrepresent Weight Loss and All Weight Metrics Poorly Predict Early Glycemic Outcome After Metabolic and Bariatric Surgery.
• A 10-Year Cost-Effectiveness Analysis of Metabolic and Bariatric Surgery in Adolescents.
• Extreme Obesity (BMI ≥ 60 kg/m²) Characterization Up to and Beyond 80 kg/m² in 1,262,454 Bariatric Surgery Patients.
• Trends in Metabolic and Bariatric Surgery Among Adolescents, 2016-2025.
• Intestinal HIF1α Is Dispensable for Bariatric Surgery-Mediated Metabolic Benefits but Protects Against Diet-Induced Obesity and Hepatic Steatosis.
• Six-Month Weight Loss and Comorbidity Remission After Sleeve Gastrectomy, Roux-En-Y Gastric Bypass, BPD-DS, and SADI-S: Propensity Score Analysis Using the 2023 MBSAQIP Database.

Drugs

• RCT: Efficacy and Safety of Mazdutide in Adults with Obesity or Overweight.
• Podcast: Baylor College of Medicine Faculty Peter H. Jones, MD, MNLA, and Christie M Ballantyne, MD, MNLA Discuss Plozasiran and the SHASTA-3 & SHASTA-4 Trial Results.
• Meta-Analysis: Comparative Efficacy and Safety of Glucagon-Like Peptide 1 Based Drugs for Weight Loss in Adults with Overweight or Obesity Without Diabetes.
• Comparative Effectiveness of GLP-1 Receptor Agonists Versus Mineralocorticoid Receptor Antagonists as Fourth-Line Pharmacological Therapy in Patients with Resistant Hypertension and Overweight or Obesity.
• Systematic Review: Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acquired Hypothalamic Obesity.
• Meta-Analysis: The Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) on Binge Eating in Patients with Obesity.
• Postmarketing Safety Signals and Medication-Use Risks of GLP-1-Based Therapies in Diabetes and Obesity.
• Meta-Analysis: Comparative Efficacy of Tirzepatide Versus Semaglutide for Weight Loss in Adults with Overweight or Obesity.

Food & Diet

• Systematic Review: "Healthy eating strategies in convenience stores show promise for improving diet-related outcomes."
• Long-Term Weight Maintenance After a Low-Carbohydrate Diet: A Real-World Retrospective Cohort Study.
• Meta-Analysis: "Mediterranean diet produced modest improvements in BMI and triglycerides but did not demonstrate clear superiority over comparator diets for most metabolic or hepatic outcomes"
• RCT: Effects of Cinnamon Supplementation Combined with Exercise Training on Anthropometric Indices and Reproductive Hormones in Women with Overweight or Obesity.

Caloric and Dietary Restriction

• Beyond Weight Loss: Disentangling the Direct Effects of Semaglutide vs Equivalent Calorie Restriction on Reproductive Systems of Male and Female Rats.
• Biological Pathways of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Adults Without Obesity.
• Review: Protein Restriction and the Hallmarks of Aging: A Coordinated Physiological Adaptive Response?

Exercise & Physical Activity

• Long-Term Physical Activity and Risk of Obesity in Australian Women Using Target-Trial Emulation: An OBCT Study.
• RCT: Effects of 12-Week Supervised Combined Aerobic and Resistance Training on Body Composition and Physical Function in Adults with Oveweight or Obesity and Multiple Cardiometabolic Risk Factors.
• Commentary: How Fast Do You Actually Lose Progress When You Stop Exercising?

Economics & Sociology

• Childhood Adiposity and Labor Market Outcomes: Mendelian Randomization Evidence on the Role of Education.
• Preprint: Household Shocks and Child Nutrition: Evidence from Young Lives Study in India.
• Social Media Discussions of Anti-Diabetic Drugs and the Popularity of GLP-1 Therapies: Content Analysis.
• Health and Economic Burden of Obesity and Obesity-Related Health Disorders in Japan.
• Does digital infrastructure improve individuals' body weight? A quasi-natural experiment based on "Broadband China" policy.
• Racialized Incorporation, Migration Timing, and Cardiometabolic Risk Among Afro-Caribbean Immigrants in the United States.
• Multilevel Effects of Socioeconomic Factors on the Somatic Status of Contemporary Youth Across Russian Regions.
• Preprint: Macroeconomic Burden of Six Major Metabolic Diseases in Low- and Middle-Income Countries: A Value of Lost Welfare Analysis Based on the Global Burden of Disease Study 2023.

Epidemiology

• The Relationship between Overweight or Obesity, Elevated Blood Pressure and the Overall Quality of Life in Medical Students, Poland.
• Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice.
• The Cost of Internet Use: An Examination of the Causal Impact on Body Weight.
• BMI Modifies Cardiovascular Risk Across Blood Pressure Categories, Particularly Among Underweight Adults with Hypertension: A 6.3 Million-person Nationwide Japanese Cohort Study.
• Causal Adiposity and Clinical Validation of Regional Fat Distribution in PMOS: A Multi-Modal Analysis Integrating GBD 2021, Mendelian Randomization, and Machine Learning.
• Preprint: Hard to Lose, Easy to Gain; Trends in Obesity and Weight Change Across the Life Course in Four British Birth Cohorts.
• A Multi-Ancestry Polygenic Risk Score for BMI Predicts Longitudinal Weight Change.
• Body Composition Phenotypes Are Key Predictors of Cardiovascular-Kidney-Metabolic Multimorbidity and Long-Term Mortality: Insights from a Population-Based Cohort Study.

Psychology & Neuroscience

• Baseline Mental Health Status and Early Psychiatric Outcomes After Metabolic-Bariatric Surgery.
• Mentalization and Dysfunctional Eating Behaviors: The Mediating Role of Emotional Regulation.
• RCT: Pregnancy Diet Based on Ancestral Patterns Increases Growth in Subcortical Fetal Brain Regions.
• Identification of Cognitive Factors That Predict Behavioural Weight-Loss Intervention Outcomes.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• "The Weight of Place:" Neighborhood Disadvantage in Adolescence and Obesity Trajectories Into Early Midlife.
• Lifestyle Interventions for Obesity Prevention Among Adolescents in Pacific Islands Countries and Territories: A Narrative Review of Outcomes and Sociocultural, Spatial and Temporal Dimensions.
• Childhood Misfortunes and Metabolic Syndrome in Old Age: European Prospective Cohort Study.

Ethics

• Silencing the Sirens: Weight-Loss Drugs, Food Noise, and the Ethics of Effortless Self-Control.
• GLP-1 Receptor Agonists in Dermatology: Ethical Considerations.

Stigma

• Assessing Underlying Processes of Implicit Weight Bias: A Diffusion Model Analysis.
• Challenging Weight Stigmatizing Perspectives in Public Health During Pregnancy by Sharing Positive Stories and Images by Those Who Have Lived Experience.
• Associations between Parental Beliefs About Their Child's Weight Controllability, Negative Weight Comments, and Initiation of Weight Talk with Children.

Policy Related

• Medicare Spending Implications for Semaglutide Under Voluntary Price Agreements.
• Opinion: Potential Effects of Sugar-Sweetened Beverage Taxation on Oral and Systemic Health Outcomes.
• Changes in Semaglutide Fills Following Expanded FDA and Medicare Policies.
• Sugar-Sweetened Beverage Tax and Dental Caries, Periodontitis and Edentulism in Australia: a Modeling Study.
• Review: Public Health Interventions for the Prevention and Management of Overweight and Obesity in Children and Adolescents.

Intergenerational Effects

• Maternal BMI, Gestational Weight Gain, and Cardiovascular Disease in Offspring.
• Impact of Prepregnancy BMI in Low-Risk Pregnancies with Adequate Gestational Weight Gain: Trend and Adverse Outcomes.
• Maternal Consumption of Fruits, Vegetables and Fruit Juices in Relation to Offspring Weight at 4 Years.

Ecology, Evolution, & Energetics

• Visceral Adiposity Is Independently Associated with Hypertension.
• Climate Risks for the European Food System and Policy Preparedness.
• Coping with the Cold: Black-Capped Chickadees (Poecile atricapillus) Use Rapid Facultative Hypothermia to Reduce Fat Loss Overnight.
• Organ Size and Metabolic Rate Co-Vary with Dimensions of the Obstetric Pelvis: The Metabolic Coordination of Childbirth Hypothesis.

Methods

• Simultaneous Prediction of Multiple Dimensions of Food Security.
• Divergent Obesity Classification between the Edmonton Obesity Staging System and the Lancet Commission Model.

Commentary

• Podcast: Should Pregnant & Breastfeeding Women Take DHA? And Should Vegan Women Supplement with DHA During Pregnancy?
• Only 30% of Global Food Supply Calcium Is Bioavailable, Study Finds.
• Podcast: Healthy Beginnings Start with Both Parents: The Emerging Science of Paternal Nutrition with Dr. Kozeta Miliku.
• Podcast: Protein-Maxxing: Is It Actually Bad for Us?
• Podcast: Why Your Brain Thinks You're Full (Even When You're Not).
• GLP-1 Drugs for Aging?
• (Un) Intended Consequences of Mass-Prescribing GLP-1s.
• Obesity Medicines as Disruptive Innovation.
• Do We Need Body Composition Analysis in Patients with Obesity? A Rethinking of Body Composition Assessment in Preclinical and Clinical Obesity.

General

• Podcast: "Scientists stripped a cell down to its most essential genes in order to find out what makes life...alive. What they found was more bizarre than they could have imagined."
• Cellular Senescence Links Muscle Atrophy and Posttraumatic Osteoarthritis After ACL [Anterior Cruciate Ligament] Injury.
• The Knotty Problem of RNA Structure Prediction.
• The Conversations That Move Science Forward.
• Podcast: Industry Innovations | Episode 7: A New Era for FCS: Diagnosis, Daily Life & the Science That's Changing Everything.
• Oxygenaging: A Physiological Framework for Geroscience.
• Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives.
• The Urinary Pathobiont Actinobaculum massiliense Can Generate Androgens Via the DirAB Pathway.
• Gut Microbiota-Derived Imidazole Propionate Promotes Primary Sclerosing Cholangitis Via p38 Signalling.
• When Answers are Instant: Why Mentorship Matters More in the Age of Artificial Intelligence.

Video & Audio

• Podcast: Why Your Body Chooses Sugar over Fat.
• Enriching Clinical Trials with Machine Learning.
• The Sleep-Weight Connection.
• How Hormones Impact Food Noise with Dominique Ludwig - YouTube.

Announcements

• ILSI Europe Develops Framework to Help Food Industry Rank Microbial Risks of Dried Ingredients.
• Virtual Event: Human Health Effects of Interesterified Fats and Oils. September 28, 2026.